Evidence map›Paper›PMID 32519306›Full record

ArticleNatural products and bioprospecting2020

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents.

Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Tianrui Zhao, Guiguang Cheng

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Meilian YangFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Yudan WangFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Zhifeng FanFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Qingwang XueDepartment of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China.
Guy Sedar Singor NjatengState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People's Republic of China.
Yaping LiuFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Jianxin CaoFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Tianrui ZhaoFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. food363@163.com.
Guiguang ChengFaculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. chengguiguang@163.com.ORCID http://orcid.org/0000-0002-5553-8399
Kunming University of Science and Technology · CNKunming Institute of Botany · CNLiaocheng University · CN

Funding

Applied Basic Research Foundation of Yunnan Province 2017FD121Applied Basic Research Foundation of Yunnan Province 2018FB036National Natural Science Foundation of China 31600274State Key Laboratory of Phytochemistry and Plant Resources in West China P2018-KF08
6 · The paper itself

Abstract

Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture. In order to further exploit their potential uses, its anti-inflammatory and immunosuppressive activities, safety evaluations and chemical profiles have been illustrated. Compared to the crude methanol extract from M. henryi and its non-alkaloidal fraction, the total alkaloidal fraction (MHTA) had the strongest anti-inflammatory and immunosuppressive activities. In the acute oral toxicity assay, the half lethal dose (LD

Indexed as

Acute toxicityMelodinus henryiMonoterpenoid indole alkaloidsSubacute toxicity

Identifiers

PMID32519306
PMCPMC7367981
OpenAlexW3032939442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.