Evidence map›Paper›PMID 32519295›Full record

ArticleBiomolecular NMR assignments2020

Anissa Belfetmi, Mélissa Léger-Abraham

Open access · hybridAbstract read
In one paragraph

Article in Biomolecular NMR assignments, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Computational study on the allosteric mechanism ofComputational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anissa BelfetmiDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-7270-2218
Mélissa Léger-AbrahamDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA. melissa_leger-abraham@hms.harvard.edu.ORCID 0000-0001-9374-0718
Harvard University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The translation apparatus of Leishmania: from basic analysis to pursuit of novelR01AI108718 · NIAID · HARVARD MEDICAL SCHOOL · PI WAGNER, GERHARD · 2014 to 2017
$1.4M
Structural Basis for Translation Initiation in Leishmania MajorR21AI156087 · NIAID · HARVARD MEDICAL SCHOOL · PI LEGER-ABRAHAM, MELISSA · 2021 to 2022
$465k
NCATS NIH HHS UL1 TR001102NIAID NIH HHS R01 AI108718NIAID NIH HHS R21 AI156087
6 · The paper itself

Abstract

Most of the translational control of gene expression in higher eukaryotes occurs during the initiation step of protein synthesis. While this process is well characterized in mammalian cells, it is less defined in parasites, including the ones that cause human Leishmaniasis. The Leishmania cap-binding isoform 1 (LeishIF4E-1) is the only isoform that binds the specific trypanosomatids-specific hypermethylated 5' cap, called cap-4, in the human stage of the parasite life cycle. We report here the extensive NMR resonance assignment of LeishIF4E-1 bound to a cap analog, m

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyAmino Acid SequenceEukaryotic Initiation Factor-4ENitrogen IsotopesProtozoan ProteinsRNA Cap AnalogsRNA Caps7-methylguanosine triphosphateEukaryotic Initiation Factor-4ENitrogen-15Nitrogen IsotopesProtozoan ProteinsRNA Cap AnalogsRNA CapsLeishIF4E-1LeishmaniaNMRTranslation initiation

Identifiers

PMID32519295
PMCPMC7462832
OpenAlexW3033284854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.