Evidence map›Paper›PMID 32519288›Full record

ArticleJournal of clinical immunology2020

Proteomic Analysis of the Acid-Insoluble Fraction of Whole Saliva from Patients Affected by Different Forms of Non-histaminergic Angioedema.

Davide Firinu, Morena Arba, Federica Vincenzoni, Federica Iavarone, Giulia Costanzo, Tiziana Cabras, Massimo Castagnola, Irene Messana, Stefano R Del Giacco, Maria T Sanna

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In one paragraph

Article in Journal of clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Davide FirinuDept of Medical Sciences and Public Health, University of Cagliari, 09042, Monserrato, CA, Italy. davide.firinu@unica.it.ORCID 0000-0002-5768-391X
Morena ArbaDept of Life and Environmental Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.
Federica VincenzoniDept of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of Sacred Heart, Rome, Italy.
Federica IavaroneDept of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of Sacred Heart, Rome, Italy.
Giulia CostanzoDept of Medical Sciences and Public Health, University of Cagliari, 09042, Monserrato, CA, Italy.
Tiziana CabrasDept of Life and Environmental Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.
Massimo CastagnolaProteomics Lab. IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano, 64 00143, Rome, Italy.
Irene MessanaIstituto di Scienze e Tecnologie Chimiche, "Giulio Natta" Consiglio Nazionale delle Ricerche L.go F. Vito 1, 00168, Roma, Italy.
Stefano R Del GiaccoDept of Medical Sciences and Public Health, University of Cagliari, 09042, Monserrato, CA, Italy.
Maria T SannaDept of Life and Environmental Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.
University of Cagliari · ITUniversità Cattolica del Sacro Cuore · ITFondazione Santa Lucia · ITIstituto per le Tecnologie Didattiche · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed by bidimensional electrophoresis the acid-insoluble fraction of saliva from three classes of angioedema patients and a healthy control group, highlighting significant variations of several normalized spot volumes. Characterization of the corresponding proteins was performed by in-gel tryptic digestion of the spots, followed by high-resolution HPLC-ESI-MS/MS analysis of tryptic mixtures. By this strategy, 16 differentially-expressed proteins among two or more groups were identified. We found higher concentration of proteins involved in immune response (interleukin-1 receptor antagonist and annexin A1), and of moonlighting proteins acting as plasminogen receptors (glyceraldehyde-3-phosphate dehydrogenase, α-enolase, and annexin A2) in patients affected by the idiopathic non-histaminergic or hereditary angioedema with unknown origin with respect to healthy controls. These data provide new information on the molecular basis of these less characterized types of angioedema. Graphical Abstract Graphical Abstract.

Indexed as

ProteomeProteomicsAdolescentAdultAgedAnalysis of VarianceAngioedemaBiomarkersCase-Control StudiesChromatography, High Pressure LiquidDisease SusceptibilityFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansImmunomodulationBiomarkersProteome2-dimensional electrophoresisAngioedemaHuman salivaMass spectrometryTandem mass spectrometry

Identifiers

PMID32519288
OpenAlexW3033772484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.