Evidence map›Paper›PMID 32519284›Full record

ReviewCurrent osteoporosis reports2020

Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.

Marco Invernizzi, Alessandro de Sire, Stefano Carda, Konstantinos Venetis, Filippo Renò, Carlo Cisari, Nicola Fusco

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Review
  4. Context-dependent roles of 11β-HSD1 in bone and skeletal muscle diseases.American journal of translational research · 2026
    Review
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  15. Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marco InvernizziPhysical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. marco.invernizzi@med.uniupo.it.ORCID 0000-0001-5141-0681
Alessandro de SirePhysical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Stefano CardaNeuropsychology and Neurorehabilitation Service, Department of Clinical Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Konstantinos VenetisPh.D. Program in Translational Medicine, University of Milan, Milan, Italy.
Filippo RenòInnovative Research Laboratory for Wound Healing, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Carlo CisariPhysical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Nicola FuscoDivision of Pathology, IRCCS European Institute of Oncology (IEO), Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI. RECENT

findingsSeveral studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.

Indexed as

Adaptor Proteins, Signal TransducingAdipokinesAminoisobutyric AcidsBone and BonesCell Adhesion MoleculesCollagenFibroblast Growth FactorsFibronectinsHumansInsulin-Like Growth Factor IInterleukin-6Mitochondria, MuscleMuscle, SkeletalMyostatinOsteocytesOsteogenesis3-aminoisobutyric acidAdaptor Proteins, Signal TransducingAdipokinesAminoisobutyric AcidsC1QTNF5 protein, humanCell Adhesion MoleculesCollagenFibroblast Growth FactorsFibronectinsFNDC5 protein, humanInsulin-Like Growth Factor IInterleukin-6Metrnl protein, humanMyostatinPOSTN protein, humanSOST protein, humanBoneBone lossMuscleOsteoporosisRehabilitationSarcopeniaSpinal cord injury

Identifiers

PMID32519284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.