Evidence map›Paper›PMID 32519199›Full record

ArticleJournal of endocrinological investigation2021

Association of MICA gene polymorphisms with thionamide-induced agranulocytosis.

P Ma, P Chen, J Gao, H Guo, S Li, J Yang, J Lai, X Yang, B Zhang, Y He

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

P MaDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
P ChenDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
J GaoCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
H GuoDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
S LiCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
J YangCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
J LaiCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
X YangCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
B ZhangCollege of Medicine and Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. zhangbao_814@mail.xjtu.edu.cn.ORCID http://orcid.org/0000-0003-0320-2305
Y HeDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. heyayi205334@126.com.
Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

Fundamental Research Funds for the Central Universities xjj2017135National Key R&D Program of China 2018YFC1314800National Natural Science Foundation of China No.31301949Shaanxi Provincial Natural Science Foundation of China 2017JQ8010; 2017SF-171
6 · The paper itself

Abstract

backgroundThionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 10

methodsWe evaluated the associations of 23 candidate single nucleotide polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves' disease (GD) as controls by iPLEX MassARRAY system.

resultsFive SNPs in the MHC class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA after Bonferroni correction. After combining with previous data of rs4349859 and HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95% CI 3.63-60.77).

conclusionOur findings suggest that five high linked SNPs of MICA gene are significantly associated with susceptibility to TIA.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgranulocytosisAntithyroid AgentsCase-Control StudiesFemaleFollow-Up StudiesGraves DiseaseHistocompatibility Antigens Class IHumansMalePrognosisAntithyroid AgentsHistocompatibility Antigens Class IMHC class I-related chain AAssociationGraves’ diseaseMICAThionamide-induced agranulocytosis

Identifiers

PMID32519199
OpenAlexW3032918127

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.