Evidence map›Paper›PMID 32519116›Full record

ReviewDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2020

[From human terrestrial models to new preventive measures for ocular changes in astronauts : Results of the German Aerospace Center studies].

J Jordan, C E Hellweg, E Mulder, C Stern

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Space-eye-disease: outer space, eye and glaucoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J JordanInstitut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Linder Höhe, 51147, Köln, Deutschland. jens.jordan@dlr.de.
C E HellwegInstitut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Linder Höhe, 51147, Köln, Deutschland.
E MulderInstitut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Linder Höhe, 51147, Köln, Deutschland.
C SternInstitut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Linder Höhe, 51147, Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOcular changes in astronauts, particularly the spaceflight associated neuro-ocular syndrome (SANS), pose a medical challenge for which no suitable preventive measures exist. During long-duration spaceflight missions, e.g. to the Moon and Mars, SANS and radiation-induced cataract could affect the health and performance of crews and jeopardize the success of missions. Mechanistic studies and development of preventive measures require suitable terrestrial models.

objectiveOverview on the most recent research and future plans in space medicine. MATERIAL AND

methodsSearch for relevant publications using PubMed.

resultsBed rest studies at the German Aerospace Center (DLR) demonstrated that strict bed rest in a -6° head down tilt position reproduces changes just like SANS on Earth. This model including creation of optic disc edema is applied in human studies testing influences of artificial gravity through short arm centrifugation as a preventive method. The unique research facility :envihab provides the opportunity to also simulate the ambient conditions of the International Space Station during bed rest studies.

conclusionFuture head down tilt bed rest studies will serve to systematically test preventive measures for SANS. Similar investigations would be difficult to realize under real space conditions. Through close collaboration between space medicine and terrestrial ophthalmology, this research can benefit patients on Earth.

Indexed as

AstronautsSpace FlightEyeHumansPapilledemaVision, OcularBed rest studiesHead down tiltMicrogravityOptic disc edemaSpaceflight associated neuro-ocular syndrome (SANS)

Identifiers

PMID32519116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.