Evidence map›Paper›PMID 32518970›Full record

ArticleNeuroradiology2020

Multiparametric flow analysis using four-dimensional flow magnetic resonance imaging can detect cerebral hemodynamic impairment in patients with internal carotid artery stenosis.

Takahiro Ando, Tetsuro Sekine, Yasuo Murai, Erika Orita, Ryo Takagi, Yasuo Amano, Kotomi Iwata, Masatoki Nakaza, Masashi Ogawa, Makoto Obara and 1 more

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Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Takahiro AndoDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. s07008ta@gmail.com.ORCID http://orcid.org/0000-0001-6673-3504
Tetsuro SekineDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Yasuo MuraiDepartment of Neurological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Erika OritaDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Ryo TakagiDepartment of Radiology, Nihon University School of Medicine, 1-6 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101-8309, Japan.
Yasuo AmanoDepartment of Radiology, Nihon University School of Medicine, 1-6 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101-8309, Japan.
Kotomi IwataDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Masatoki NakazaDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Masashi OgawaDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Makoto ObaraPhilips Electronics Japan Healthcare, 2-13-37 Kounan, Minato-ku, Tokyo, 108-8507, Japan.
Shin-Ichiro KumitaDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Nippon Medical School · JPNihon University · JP

Funding

Hitachi Global Foundation 1309Japan Society for the Promotion of Science 17K18160Japan Society for the Promotion of Science 19K08186Japan Society for the Promotion of Science 19K17151
6 · The paper itself

Abstract

purposeMRI-based risk stratification should be established to identify patients with internal carotid artery stenosis (ICS) who require further PET or SPECT evaluation. This study assessed whether multiparametric flow analysis using time-resolved 3D phase-contrast (4D flow) MRI can detect cerebral hemodynamic impairment in patients with ICS.

methodsThis retrospective study analyzed 26 consecutive patients with unilateral ICS (21 men; mean age, 71 years) who underwent 4D flow MRI and acetazolamide-stress brain perfusion SPECT. Collateral flow via the Willis ring was visually evaluated. Temporal mean flow volume rate (Net), pulsatile flow volume (ΔV), and pulsatility index (PI) at the middle cerebral artery were measured. Cerebral vascular reserve (CVR) was calculated from the SPECT dataset. Patients were assigned to the misery perfusion group if the CVR was < 10% and to the nonmisery perfusion group if the CVR was ≥ 10%. Parameters showing a significant difference in both groups were statistically evaluated.

resultsAffected side ΔV, ratio of affected to contralateral side Net (rNet), and ratio of affected to contralateral side ΔV were significantly correlated to CVR (p = 0.030, p = 0.010, p = 0.015, respectively). Absence of retrograde flow at the posterior communicating artery was observed in the misery perfusion group (p = 0.020). Combined cut-off values of the affected side ΔV (0.18 ml) and rNet (0.64) showed a sensitivity and specificity of 100% and 77.8%, respectively.

conclusionMultiparametric flow analysis using 4D flow MRI can detect misery perfusion by comprehensively assessing blood flow data, including blood flow volume, pulsation, and collateral flow.

Indexed as

Cerebrovascular CirculationHemodynamicsAgedBlood Flow VelocityCarotid Artery, InternalCarotid StenosisCerebrovascular DisordersCircle of WillisFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleRetrospective StudiesTomography, Emission-Computed, Single-PhotonBlood flowInternal carotid artery stenosisMagnetic resonance imagingMisery perfusionPulsatile flowTime-resolved 3D phase contrast

Identifiers

PMID32518970
OpenAlexW3033462291

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.