ArticleWorld journal of clinical cases2020
Serum von Willebrand factor for early diagnosis of lung adenocarcinoma in patients with type 2 diabetes mellitus.
Article in World journal of clinical cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 12 citations in OpenAlex.
- Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer.Biological procedures online · 2023Article
- Potential Prognostic Biomarkers of Lung Adenocarcinoma Based on Bioinformatic Analysis.BioMed research international · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundThe elevation of plasma von Willebrand factor (vWF) has been proposed to be a predictor of lung cancer. Type 2 diabetes mellitus (T2DM) causes endothelial activation, resulting in the secretion of vWF. However, the role of vWF in patients with T2DM complicated with lung cancer remains unclear.
aimTo investigate the clinical value of serum vWF as a tumor marker in patients with T2DM combined with lung adenocarcinoma
methodsThis study enrolled 43 patients with T2DM combined with lung AIS (T2DM + AIS group), 43 patients with T2DM alone (T2DM group), 43 patients with lung AIS alone (AIS group), and 43 healthy volunteers (control group). The serum levels of vWF, insulin-like growth factor 1, and insulin-like growth factor binding protein 3 were determined. Multiple linear stepwise regression was performed to determine the correlations among variables.
resultsSerum concentration of vWF in the T2DM + AIS group was significantly higher than those in the T2DM, AIS, and control groups (
conclusionSerum vWF level may represent a novel biomarker for the early diagnosis of lung AIS.
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