ArticlePeerJ2020
Role of echocardiography in screening for portopulmonary hypertension in liver transplant candidates: a meta-analysis.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic and prognostic value of echocardiography in pulmonary hypertension: an umbrella review of systematic reviews and meta-analyses.BMC pulmonary medicine · 2023Pooled it
- Clinical aspects encountered in patients with portopulmonary hypertension.Medicine and pharmacy reports · 2025Review
- Article
- Echocardiographic Screening of Liver Transplant Candidates-Prevalence of Features of Portopulmonary Hypertension.Journal of clinical medicine · 2024Article
- Portopulmonary Hypertension: An Updated Review.Transplantation direct · 2023Review
- Simple algorithm to narrow down the candidates to receive echocardiography in patients with chronic liver disease for suspected pulmonary hypertension.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo demonstrate the screening value of echocardiography for portopulmonary hypertension (POPH) in liver transplant candidates.
designSystematic review and meta-analysis.
backgroundPOPH is a complication of end-stage liver disease that adversely affects the outcome of orthotopic liver transplant. There are no specific symptoms in the early stage of POPH. POPH reduce the survival rate of patients with end-stage liver disease specially if they are not diagnosed. Therefore, early detection may improve prognosis. The objective of this study is to explore the screening value of echocardiography on liver transplant candidates for screening of POPH compared to right heart catheterization (RHC).
methodPubMed, EMBASE and the Cochrane Library were searched by two independent reviewers for potentially eligible studies published up to 30 June 2019 to retrieve data based on per-patient analysis. STATA, Meta-DiSc, and RevMan were applied to perform this meta-analysis.
resultsOur search yielded 1576 studies, of which 11 satisfied the inclusion criteria. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the summary receiver operating characteristic (SROC) curve (AUC) of echocardiography for POPH were 0.85 (95% CI [0.65-0.94]), 0.83 (95% CI [0.73-0.90]), 4.99 (95% CI [3.03-8.21]), 0.19 (95% CI [0.07-0.46]), and 0.91 (95% CI [0.88-0.93]), respectively. Deeks' funnel plot did not indicate the existence of publication bias (
conclusionsEchocardiography, a noninvasive modality, provides superior screening for POPH, but the diagnosis of POPH still requires RHC.
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