ArticleInternational journal of retina and vitreous2020
Outer retina changes on optical coherence tomography in vitamin A deficiency.
Article in International journal of retina and vitreous, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Ocular manifestations of vitamin A deficiency in gastrointestinal and hepatobiliary disease.Frontiers in ophthalmology · 2026Article
- Xerophthalmia and Nyctalopia as Presenting Signs of Vitamin A Deficiency in a Patient With Rapid Intentional Weight Loss: A Case Report and Literature Review.Clinical case reports · 2025Article
- Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Electrophysiological assessment of nutritional optic neuropathy: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2023Review
- Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency.American journal of ophthalmology case reports · 2023Article
- Dent disease presenting with nyctalopia and electroretinographic correlates of vitamin A deficiency.American journal of ophthalmology case reports · 2023Article
- A comparison of optophysiological biomarkers of photoreceptor stress and phototoxicity in BALB/cJ, B6 (Cg)-Tyrc-2J/J, and C57Bl/6J mouse strains.Frontiers in ophthalmology · 2023Article
- Documentation of recovery from vitamin A deficiency-related retinopathy via multimodal imaging and electroretinogram testing.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Multicolor Imaging Highlights Xerophthalmic Fundus.Journal of ophthalmic & vision researchArticle
- Throwing light on night blindness associated with rare manifestation of vitamin A deficiency.Romanian journal of ophthalmologyArticle
- Choroidal Thickening and Outer Retinal Alterations in Vitamin A Deficiency: A Case Report.Case reports in ophthalmologyArticle
- A Case of Autism Spectrum Disorder with Perforated Keratomalacia due to Vitamin A Deficiency.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. CASE PRESENTATION: We present two cases with symptoms of severe nyctalopia who were subsequently diagnosed with severe Vitamin A deficiency and their unique findings on SD-OCT of outer nuclear layer diffuse thinning with irregular appearance of the interdigitating zone and the ellipsoid zone as well as normalization after vitamin A supplementation.
conclusionsOuter nuclear layer thinning and disruption of the outer retinal bands on SD-OCT are reversible with correction of vitamin A deficiency. Improvement in visual acuity, color vision, and nyctalopia are possible with early diagnosis and appropriate treatment.
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