ArticleFuture science OA2020
Increasing the public activity cliff knowledge base with new categories of activity cliffs.
Article in Future science OA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Cheminformatics Approaches to the Analysis of Additives for Sustainable Polymeric Materials.Polymers · 2025Article
- Progress on open chemoinformatic tools for expanding and exploring the chemical space.Journal of computer-aided molecular design · 2022Article
- Automatic Identification of Analogue Series from Large Compound Data Sets: Methods and Applications.Molecules (Basel, Switzerland) · 2021Review
- Increasing the public activity cliff knowledge base with new categories of activity cliffs.Future science OA · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimExtending the public knowledge base of activity cliffs (ACs) with new categories of ACs having special structural characteristics. METHODOLOGY: Dual-site ACs, isomer ACs and ACs with privileged substructures are described and their systematic identification is detailed. EXEMPLARY RESULTS & DATA: More than 7400 new ACs belonging to different categories with activity against more than 200 targets were identified and are made publicly available. LIMITATIONS & NEXT STEPS: For dual-site ACs, limited numbers of isomers are available as structural analogs for rationalizing contributions to AC formation. The search for such analogs will continue. In addition, the target distribution of ACs containing privileged substructures will be further analyzed.
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Registered trials
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