ReviewFuture science OA2020
Biliary atresia: pathology, etiology and pathogenesis.
Review in Future science OA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Comparison for the diagnostic performance of early diagnostic methods for biliary atresia: a systematic review and network meta-analysis.Pediatric surgery international · 2024Pooled it
- Population-based screening strategies for biliary atresia in the newborn: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Ductular Reaction Underlies Development of Portal Hypertension in Biliary Atresia.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- The characteristics of liver nodules in biliary atresia native liver survivors.Pediatric surgery international · 2026Article
- Prenatal biliary imaging for the diagnosis of biliary atresia: a protocol for a multicentre prospective diagnostic accuracy study.BMJ open · 2026Article
- Association of postoperative infection with early bilirubin clearance and native liver survival: a single - center retrospective cohort study.BMC pediatrics · 2026Article
- RNA-Binding Proteins Alter Redox Gene Splicing in Biliary Atresia: Insights from Expression Profiling.ACS omega · 2026Article
- A prognostic analysis of cystic and non-cystic biliary atresia.Surgical endoscopy · 2026Article
- Biliary atresia, splenic malformation, and situs inversus managed with Kasai portoenterostomy: case report.International journal of surgery case reports · 2026Article
- Lack of association between cytomegalovirus infection and liver fibrosis in patients with biliary atresia after the Kasai procedure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026Review
- Immunohistochemical Expression of HLA Classes I and II in Neonatal Cholestatic Liver Disease.Iranian journal of pathology · 2026Article
- A two-hit model in biliary atresia: cooperative viral-bacterial activation of MMP7 via TLR4/NF-κB signaling.Pediatric research · 2025Article
- Varied Characteristics of Recovered Patients with Biliary Atresia.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Observational
- Prompt distinction of Alagille syndrome and biliary Atresia in infants: a comparative study.BMC pediatrics · 2025Article
- Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis.JCI insight · 2025Article
- Dramatic Extrahepatic Cholestasis Improvement after Steroid Therapy.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- Blockade of B-cell-activating factor may alleviate liver injury by restraining interferon-γ expression in T cells in experimental biliary atresia.Pediatric surgery international · 2025Article
- Vitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy.BMC gastroenterology · 2025Article
- Heterotaxy syndrome with biliary atresia: a case report.The Pan African medical journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice. Histopathological findings in liver biopsies include the expansion of the portal tracts, with edematous fibroplasia and bile ductular proliferation, with bile plugs in duct lumen. Lobular morphological features may include variable multinucleate giant cells, bilirubinostasis and hemopoiesis. The etiopathogenesis of biliary atresia is multifactorial and multiple pathomechanisms have been proposed. Experimental and clinical studies have suggested that viral infection initiates biliary epithelium destruction and release of antigens that trigger a Th1 immune response, which leads to further injury of the bile duct, resulting in inflammation and obstructive scarring of the biliary tree. It has also been postulated that biliary atresia is caused by a defect in the normal remodelling process. Genetic predisposition has also been proposed as a factor for the development of biliary atresia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.