ArticleTropical diseases, travel medicine and vaccines2020
Temperature integrity and exposure of vaccines to suboptimal temperatures in cold chain devices at different levels in three states of India.
Article in Tropical diseases, travel medicine and vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Immunobiological cold chain performance assessment in Brazil: mixed methods research.BMC health services research · 2026Article
- Understanding Ukraine's immunization supply chain resilience in the face of war: a mixed-method study.Conflict and health · 2026Article
- Article
- Preventive strategies for chronic liver disease: A critical review of awareness, vaccine and screening programmes.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Evaluation of enterovirus A71 vaccine effectiveness against pediatric hand, foot, and mouth disease caused by enterovirus A71 virus in Tianjin, China, 2016-2023: A test-negative design case-control study.Human vaccines & immunotherapeutics · 2025Article
- Assessment of eVIN (Electronic Vaccine Intelligence Network) in utility and constraints of various stakeholders in Nainital District: A mixed method study.Journal of family medicine and primary care · 2025Article
- Assessment of vaccine management performance in health facilities of Mwanza Region, Tanzania: a cross-sectional study.Journal of pharmaceutical policy and practice · 2023Article
- Vaccine management practices among healthcare workers in Morogoro, Tanzania: a cross-sectional study.Journal of pharmaceutical policy and practice · 2022Article
- Emvolio - A battery operated portable refrigerator preserves biochemical and haematological integrity of biological samples in preclinical studies.F1000Research · 2022Article
- Lyophilization Process Engineering and Thermostability of ID93 + GLA-SE, a Single-Vial Adjuvanted Subunit Tuberculosis Vaccine Candidate for Use in Clinical Studies.Frontiers in drug delivery · 2022Article
- Development of thermostable vaccine adjuvants.Expert review of vaccines · 2021Review
- Transdermal approaches to vaccinations in the COVID-19 pandemic era.Therapeutic advances in vaccines and immunotherapy · 2021Review
- Vaccine cold chain and understanding what underpins vaccine security for vaccine preventable diseases.BMJ medicineReview
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Authors and funding
6 authors.
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Abstract
objectiveTo document the temperature integrity at the vaccine storage devices at various levels in three states of India.
methodsA total of 213 health facilities including 196 facilities (district and sub-district levels) from 27 select districts and 17 division or state level vaccine stores in three states were included. At these facilities, temperature in 223 vaccine storage devices was recorded for at least 7 consecutive days using electronic temperature datalogger.
resultsDuring the observation period, overall the vaccines were exposed to temperature < 0 °C for 14.8% of the storage time with 8.6, 6.7 and 18% at state/division, district and sub-district vaccine stores, respectively. The vaccines were also exposed to temperature > 8 °C for 6.6% of the storage time including 1.3, 13 and 5.1% at state/division, district and sub-district vaccine stores, respectively. Continuous episodes of temperature deviation for 45 min or longer to < 0 °C and > 8 °C was observed in 7.2 and 6.4% of the observation period, respectively. These temperature deviations were not captured by the routine temperature monitoring practice.
conclusionThe vaccines were exposed to freezing temperature for a considerable period at all level stores, which was more than the exposure to higher temperature. To ensure vaccine potency and immunogenicity, stringent temperature integrity maintenance is needed at all levels.
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