Evidence map›Paper›PMID 32518617›Full record

ArticleTherapeutic advances in psychopharmacology2020

Symptomatic and functional outcomes after treatment with paliperidone palmitate 3-month formulation for 52 weeks in patients with clinically stable schizophrenia.

Maria Paz Garcia-Portilla, Pierre-Michel Llorca, Giuseppe Maina, Vasilis P Bozikas, Halise Devrimci-Ozguven, Sung-Wan Kim, Paul Bergmans, Irina Usankova, Katalin Pungor

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 9 countries.

Maria Paz Garcia-PortillaDepartment of Psychiatry, University of Oviedo, CIBERSAM, Oviedo, Spain.
Pierre-Michel LlorcaCMP B, CHU Clermont-Ferrand, Clermont Auvergne University, Clermont-Ferrand, France.ORCID https://orcid.org/0000-0001-7438-8990
Giuseppe MainaSCDU Psichiatria, AOU San Luigi Gonzaga, Università degli Studi di Torino, Torino, Piemonte, Italy.
Vasilis P BozikasSecond Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Halise Devrimci-OzguvenDepartment of Psychiatry, School of Medicine, Ankara University, Ankara, Turkey.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea.
Paul BergmansJanssen Cilag, Biostatistics, Breda, The Netherlands.
Irina UsankovaJohnson & Johnson, EMEA Medical Affairs Organization, Moscow, Russia.
Katalin PungorEMEA Medical Affairs, Janssen Cilag GmbH, Johnson & Johnson Platz 1, Neuss, 41470, Germany.ORCID https://orcid.org/0000-0003-4679-2050
Ankara University · TRAristotle University of Thessaloniki · GRChonnam National University Hospital · KRFederal Agency for Scientific Organizations · RUJanssen (Netherlands) · NLJohnson & Johnson (Germany) · DEUniversidad de Oviedo · ESUniversité Clermont Auvergne · FRUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPaliperidone palmitate 3-monthly (PP3M) formulation is a long-acting, injectable antipsychotic treatment approved in many countries worldwide for the maintenance treatment of adult patients with schizophrenia. This single-arm, open-label, phase IIIb study evaluated the efficacy and safety of converting patients with schizophrenia stabilized with paliperidone palmitate 1-month (PP1M) to PP3M in a naturalistic clinical setting.

methodsAfter screening (days -7 to 1), patients were converted from PP1M (50-150 mg eq.) to PP3M (175-525 mg eq.), and entered a 52-week, flexible-dose PP3M treatment period. The primary efficacy endpoint was symptomatic remission (SR) (Andreasen criteria) at last observation carried forward (LOCF) endpoint.

resultsPatients (

conclusionResults from this naturalistic study were similar to those observed in previous randomized clinical trials of PP3M and underline the importance of continuous maintenance treatment in patients with schizophrenia.

Indexed as

functional remissionpaliperidone palmitate 1-monthly formulationpaliperidone palmitate 3-monthly formulationschizophreniasymptomatic remission

Identifiers

PMID32518617
PMCPMC7252374
OpenAlexW3030944846

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.