ArticleTherapeutic advances in endocrinology and metabolism2020
Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes?
Article in Therapeutic advances in endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- Meta-Analysis of Non-Alcoholic Fatty Liver Disease and Electromechanical Reconstruction of Myocardium.Archives of Razi Institute · 2022Pooled it
- Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy.Journal of advanced research · 2026Article
- Article
- Selenium Status Is Associated with Inflammation in Epicardial Adipose Tissue in Elderly Patients with Coronary Artery Disease.Antioxidants (Basel, Switzerland) · 2026Article
- Cardiometabolic associations of SGLT-2 inhibitors on epicardial adiposity and left ventricular function in type 2 diabetes mellitus with coronary artery disease: insights from Malaysian EpiCAD study.Scientific reports · 2026Article
- Impaired lymphangiogenesis in pericoronary adipose tissue correlates with diabetes-aggravated coronary atherosclerosis.Cardiovascular diabetology · 2026Article
- Systolic Versus Diastolic Echocardiographic Assessment of Epicardial Adipose Tissue for the Detection of Obstructive Coronary Artery Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Epicardial adipose tissue mediates the association between circulating hsa-miR-4750-3p and coronary artery disease in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2026Observational
- Association of metabolic score for visceral fat with cardiovascular risk and total mortality in patients with type 2 diabetes: insights from ACCORD study.Diabetology & metabolic syndrome · 2025Article
- Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study.Cardiovascular diabetology · 2025Article
- Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice.Basic research in cardiology · 2025Article
- AI-Driven segmentation and morphogeometric profiling of epicardial adipose tissue in type 2 diabetes.Cardiovascular diabetology · 2025Article
- Cardiac magnetic resonance quantified epicardial fat volume is associated with complex coronary artery disease among diabetics.Cardiovascular diabetology · 2025Article
- The Role of Obesity as a Cardiac Disease Risk Factor in Patients with Type 2 Diabetes.Current cardiology reports · 2024Review
- Metabolic Consequences of Advanced Chronic Heart Failure and its Modification by Implantation of a Durable Left Ventricular Assist Device.Reviews in cardiovascular medicine · 2024Review
- Single-Nucleus Transcriptomic Atlas of Human Pericoronary Epicardial Adipose Tissue in Normal and Pathological Conditions.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Adipocyte-mediated electrophysiological remodeling of human stem cell - derived cardiomyocytes.Journal of molecular and cellular cardiology · 2024Article
- Epicardial fat and insulin resistance in healthy older adults: a cross-sectional analysis.GeroScience · 2024Article
- The Cardiac-Kidney-Liver (CKL) syndrome: the "real entity" of type 2 diabetes mellitus.Archives of medical science : AMS · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular disease and heart failure, which highlights the need for improved understanding of factors contributing to the pathophysiology of these complications as they are the leading cause of mortality in T2D. Patients with T2D have high levels of epicardial adipose tissue (EAT). EAT is known to secrete inflammatory factors, lipid metabolites, and has been proposed to apply mechanical stress on the cardiac muscle that may accelerate atherosclerosis, cardiac remodeling, and heart failure. High levels of EAT in patients with T2D have been associated with atherosclerosis, diastolic dysfunction, and incident cardiovascular events, and this fat depot has been suggested as an important link coupling diabetes, obesity, and cardiovascular disease. Despite this, the predictive potential of EAT in general, and in patients with diabetes, is yet to be established, and, up until now, the clinical relevance of EAT is therefore limited. Should this link be established, importantly, studies show that this fat depot can be modified both by pharmacological and lifestyle interventions. In this review, we first introduce the role of adipose tissue in T2D and present mechanisms involved in the pathophysiology of EAT and pericardial adipose tissue (PAT) in general, and in patients with T2D. Next, we summarize the evidence that these fat depots are elevated in patients with T2D, and discuss whether they might drive the high cardiometabolic risk in patients with T2D. Finally, we discuss the clinical potential of cardiac adipose tissues, address means to target this depot, and briefly touch upon underlying mechanisms and future research questions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.