Evidence map›Paper›PMID 32518610›Full record

ArticleHereditary cancer in clinical practice2020

Increased risk for uterine cancer among first-degree relatives to Swedish gastric cancer patients.

Johanna Samola Winnberg, Eva Rudd, Anne Keränen, Kristina Lagerstedt-Robinson, Annika Lindblom, Magnus Nilsson, Mats Lindblad, Krister Sjödahl

Open access · goldAbstract read
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Article in Hereditary cancer in clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Johanna Samola WinnbergDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet and Department of Upper Abdominal Diseases, Karolinska University Hospital, Karolinska University Hospital Huddinge, C1:77, 14186 Stockholm, Sweden.ORCID 0000-0002-3831-4801
Eva RuddDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, and National Board of Forensic Medicine, Stockholm, Sweden.
Anne KeränenDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Kristina Lagerstedt-RobinsonDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, and Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, and Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Magnus NilssonDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet and Department of Upper Abdominal Diseases, Karolinska University Hospital, Karolinska University Hospital Huddinge, C1:77, 14186 Stockholm, Sweden.
Mats LindbladDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet and Department of Upper Abdominal Diseases, Karolinska University Hospital, Karolinska University Hospital Huddinge, C1:77, 14186 Stockholm, Sweden.
Krister SjödahlDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet and Department of Surgery, Norrtälje Hospital, Norrtälje, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SESwedish National Board of Forensic Medicine · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn order to further understand genetically predisposing factors of gastric cancer, a retrospective study on 107 patients with gastric cancer was conducted. The family history of cancer cases was registered, in search of associations between gastric cancer and other cancer types. MATERIALS AND

methodsWithin Stockholm County in Sweden, all patients previously diagnosed with gastric cancer and still alive were invited to participate in the study. Patients were asked to complete a questionnaire about their gastric cancer diagnosis and if any cancers had occurred in their family. A blood sample for DNA extraction was collected. The proportions of different cancer types in the relatives of the patients were compared to the general Swedish population in 1970 and 2010.

resultsAmong first- and second-degree relatives to the index patients with gastric cancer, the frequency of uterine cancer as well as gastric cancer was significantly overrepresented compared to the general population in Sweden. The frequency of breast cancer was significantly lower.

conclusionsThere seems to be an increased risk of both gastric cancer and uterine cancer in the families of gastric cancer survivors, indicating a possible hereditary connection between these two cancer types.

Indexed as

Gastric cancerGenetic predisposition to diseaseHereditaryNeoplastic syndromesSwedenUterine cancer

Identifiers

PMID32518610
PMCPMC7275318
OpenAlexW3033683333

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.