SynthesisInternational journal of obesity (2005)2021
Association of maternal caffeine intake during pregnancy with low birth weight, childhood overweight, and obesity: a meta-analysis of cohort studies.
Synthesis in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The maternal factors associated with infant low birth weight: an umbrella review.BMC pregnancy and childbirth · 2024Pooled it
- Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis.Epigenomics · 2023Pooled it
- Glucose Co-Treatment Modulates Caffeine-Induced Transcriptomic Alterations During Embryogenesis in Zebrafish (Biology · 2026Article
- Nutrition, Physical Activity and Other Health Aspects Before and During Pregnancy - Recommendations by the Nationwide "Healthy Start Network" (Netzwerk Gesund ins Leben) 2026.Geburtshilfe und Frauenheilkunde · 2026Article
- Maternal nutritional imbalance during pregnancy and the development of fetal-origin cardiovascular diseases.Frontiers in nutrition · 2026Review
- Pregnancy and Caffeine Metabolism: Updated Insights and Implications for Maternal-Fetal Health.Nutrients · 2025Review
- Impact of tea and coffee consumption during pregnancy on children's cognitive development.Scientific reports · 2025Article
- The Fetal Effect of Maternal Caffeine Consumption During Pregnancy-A Review.Biomedicines · 2025Review
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort.Archives of gynecology and obstetrics · 2024Article
- Beverages - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- The influence of six polymorphisms of uncoupling protein 3 (UCP3) gene and childhood obesity: a case-control study.BMC pediatrics · 2023Article
- Association of Maternal Caffeine Consumption During Pregnancy With Child Growth.JAMA network open · 2022Article
- Maternal caffeine intake and DNA methylation in newborn cord blood.The American journal of clinical nutrition · 2022Article
- Assessment of Caffeine Consumption and Maternal Cardiometabolic Pregnancy Complications.JAMA network open · 2021Article
- Careful data extraction in meta-analysis: the case of maternal caffeine intake during pregnancy and low-birth weight, childhood overweight, and obesity.International journal of obesity (2005) · 2021Article
- Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.JAMA network open · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies reported inconsistent results on the associations between maternal caffeine intake during pregnancy and risk of low birth weight (LBW) and childhood overweight and obesity in their offspring.
methodsWe conducted a meta-analysis of cohort studies to quantitatively assess these associations. Pertinent studies were identified by searching PubMed and Embase through June 2019. Study-specifics risk estimates were combined using fixed effects models, or random-effects models when significant heterogeneity was detected. Dose-response analysis was modeled by using restricted cubic splines.
resultsA total of 15 cohort studies, with 102,347 pregnancy women, was included in the meta-analysis. The pooled relative risk (RR) for LBW was 1.33 (95% CI: 1.12, 1.57) for mothers with the highest compared with the lowest level of caffeine intake during pregnancy, with significant heterogeneity across studies (I
conclusionsMaternal caffeine intake during pregnancy is associated with higher risk of LBW and childhood overweight and obesity. Further studies may focus on investigating the potential mechanisms before the recommendation of complete avoidance of caffeine intake during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.