Evidence map›Paper›PMID 32518316›Full record

ArticleScientific reports2020

High Oscillospira abundance indicates constipation and low BMI in the Guangdong Gut Microbiome Project.

Yi-Ran Chen, Hui-Min Zheng, Guo-Xia Zhang, Fang-Lan Chen, Li-Dan Chen, Zhi-Cong Yang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Review
  9. Dietary Supplementation withAnimals : an open access journal from MDPI · 2026
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  12. Association betweenBioscience of microbiota, food and health · 2026
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  13. Decoding the power of the microbiome in human health.Frontiers in cellular and infection microbiology · 2026
    Review
  14. Article
  15. Article
  16. Gut microbes · 2025
    Article
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  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yi-Ran ChenGuangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
Hui-Min ZhengDepartment of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Guo-Xia ZhangDepartment of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Fang-Lan ChenDepartment of Intensive Care Unit, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Li-Dan ChenDepartment of Laboratory Medicine, General Hospital of Southern Theatre Command of PLA, Guangzhou, Guangdong, China. 17437154@qq.com.
Zhi-Cong YangGuangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. yangzc@gzcdc.org.cn.
Guangzhou Center for Disease Control and Prevention · CNSouthern Medical University · CNShenzhen Second People's Hospital · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oscillospira is a common yet rarely cultivated gut bacterial genus. Recently human gut microbiota studies have demonstrated its underlying significance for host health. However, little is known about Oscillospira-related host information and the links between Oscillospira and other members of the gut microbial community. To study the ecology of Oscillospira and gain insights into Oscillospira-related host physiological conditions, we analyzed data from the Guangdong Gut Microbiome Project, one of the largest gut microbiota database currently. Data of 6376 participants were analyzed. We studied the prevalence and relative abundance of Oscillospira as well as the profiles of associated microbial communities. We found that Oscillospira is closely related to human health because its abundance was positively correlated with microbial diversity, high density lipoprotein, and sleep time, and was inversely correlated with diastolic blood pressure, systolic blood pressure, fasting blood glucose, triglyceride, uric acid and Bristol stool type. Moreover, random forest analysis with five-fold cross validation showed Oscillospira could be a predictor of low BMI and constipation in the subset. Overall, in this study, we provide a basic understanding of Oscillospira-related microbiota profile and physiological parameters of the host. Our results indicate Oscillospira may play a role in aggravating constipation.

Indexed as

Body Mass IndexGastrointestinal MicrobiomeChinaConstipationEubacterialesFemaleHost-Pathogen InteractionsHumansMaleMiddle Aged

Identifiers

PMID32518316
PMCPMC7283226
OpenAlexW3033182537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.