Evidence map›Paper›PMID 32518301›Full record

ArticleJournal of human hypertension2021

Changes in pre-dialysis blood pressure variability in the first year of dialysis associate with mortality in European hemodialysis patients: a retrospective cohort study on behalf of the MONDO Initiative.

Marijke J E Dekker, Len A Usvyat, Constantijn J A M Konings, Jeroen P Kooman, Bernard Canaud, Paola Carioni, Daniele Marcelli, Frank M van der Sande, Vaibhav Maheshwari, Yuedong Wang and 2 more

Abstract read
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In one paragraph

Article in Journal of human hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marijke J E DekkerMaastricht University Medical Center, Maastricht, The Netherlands. mje.dekker@gmail.com.
Len A UsvyatRenal Research Institute, New York, NY, USA.
Constantijn J A M KoningsCatharina Hospital, Eindhoven, The Netherlands.
Jeroen P KoomanMaastricht University Medical Center, Maastricht, The Netherlands.
Bernard CanaudFresenius Medical Care, Bad Homburg, Germany.
Paola CarioniFresenius Medical Care, Bad Homburg, Germany.
Daniele MarcelliFresenius Medical Care, Bad Homburg, Germany.ORCID http://orcid.org/0000-0002-7650-8578
Frank M van der SandeMaastricht University Medical Center, Maastricht, The Netherlands.
Vaibhav MaheshwariRenal Research Institute, New York, NY, USA.
Yuedong WangUniversity of California, Santa Barbara, CA, USA.
Peter KotankoRenal Research Institute, New York, NY, USA.
Jochen G RaimannRenal Research Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-8954-2783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pre-hemodialysis systolic blood pressure variability (pre-HD SBPV) has been associated with outcomes. The association of a change in pre-HD SBPV over time with outcomes, and predictors of this change, has not yet been studied. Therefore, we studied this in a cohort of 8825 incident hemodialysis (HD) patients from the European Monitoring Dialysis Outcomes Initiative database. Patient level pre-HD SBPV was calculated as the standard deviation of the residuals of a linear regression model of systolic blood pressure (SBP) over time divided by individual mean SBP in the respective time periods. The pre-HD SBPV difference between months 1-6 and 7-12 was used as an indicator of pre-HD SBPV change. The association between pre-HD SBPV change and all-cause mortality in year 2 was analyzed by multivariate Cox models. Predictors of pre-HD SBPV change was determined by logistic regression models. We found the highest pre-HD SBPV tertile, in the first 6 months after initiation of HD, had the highest mortality rates (adjusted HR 1.44 (95% confidence intervals (95% CI): 1.15-1.79)). An increase in pre-HD SBPV between months 1-6 and 7-12 was associated with an increased risk of mortality in year 2 (adjusted HR 1.29 (95% CI: 1.05-1.58)) compared with stable pre-HD SPBV. A pre-HD SBPV increase was associated with female gender, higher mean pre-HD SBP and pulse pressure, and lower HD frequency.

Indexed as

Renal DialysisBlood PressureCohort StudiesDialysisFemaleHumansRetrospective Studies

Identifiers

PMID32518301

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.