ArticleScientific reports2020
Frontoparietal connectivity correlates with working memory performance in multiple sclerosis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05291208 (Evaluation of a Cognitive Training Therapy Based on Synchronized Oscillatory Stimulation in Patients With Mild Cognitive Impairment Through a Randomized Clinical Trial), which is not on this map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Cognitive Training Therapy Based on Synchronized Oscillatory Stimulation in Patients With Mild Cognitive Impairment Through a Randomized Clinical Trial
Who cites it
24 citing papers in PubMed.
- Optimizing tACS for working memory: differential outcomes in healthy aging and non-amnestic mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- Trial
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Global neural oscillations underlie performance variability and attentional state fluctuations in humans.Scientific reports · 2026Article
- Coupling between neural oscillations and white matter integrity reveals cognitive computational profiles following COVID-19.Scientific reports · 2025Article
- White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis.Scientific reports · 2025Article
- Article
- Disrupted working memory event-related network dynamics in multiple sclerosis.Communications biology · 2024Article
- Lateral prefrontal theta oscillations causally drive a computational mechanism underlying conflict expectation and adaptation.Nature communications · 2024Article
- Theta and alpha oscillations may underlie improved attention and working memory in musically trained children.Brain and behavior · 2024Article
- Article
- The parietal cortex has a causal role in ambiguity computations in humans.PLoS biology · 2024Article
- A mechanistic insight into sources of error of visual working memory in multiple sclerosis.eLife · 2023Article
- Characterizing multiple sclerosis disease progression using a combined structural and functional connectivity metric.Magnetic resonance imaging · 2023Article
- Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?Life (Basel, Switzerland) · 2023Article
- Another in need enhances prosociality and modulates frontal theta oscillations in young adults.Frontiers in psychiatry · 2023Article
- Multistage classification identifies altered cortical phase- and amplitude-coupling in Multiple Sclerosis.NeuroImage · 2022Article
- Altered resting state functional connectivity in youth with congenital heart disease operated during infancy.PloS one · 2022Article
- Enhancing Visuospatial Working Memory Performance Using Intermittent Theta-Burst Stimulation Over the Right Dorsolateral Prefrontal Cortex.Frontiers in human neuroscience · 2022Article
- Exploring Network Properties Across Preclinical Stages of Alzheimer's Disease Using a Visual Short-Term Memory and Attention Task with High-Density Electroencephalography: A Brain-Connectome Neurophysiological Study.Journal of Alzheimer's disease : JAD · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
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