ArticleNature communications2020
A host-guest approach to combining enzymatic and artificial catalysis for catalyzing biomimetic monooxygenation.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
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- Reactivity Inside Molecular Flasks: Acceleration Modes and Types of Selectivity Obtainable.Angewandte Chemie (International ed. in English) · 2024Review
- Origins of High-Activity Cage-Catalyzed Michael Addition.Journal of the American Chemical Society · 2024Article
- Binding of Dual-Function Hybridized MetalJACS Au · 2022Article
- A host-guest semibiological photosynthesis system coupling artificial and natural enzymes for solar alcohol splitting.Nature communications · 2021Article
- Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy.ACS applied materials & interfaces · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct transfer of protons and electrons between two tandem reactions is still a great challenge, because overall reaction kinetics is seriously affected by diffusion rate of the proton and electron carriers. We herein report a host-guest supramolecular strategy based on the incorporation of NADH mimics onto the surface of a metal-organic capsule to encapsulate flavin analogues for catalytic biomimetic monooxygenations in conjunction with enzymes. Coupling an artificial catalysis and a natural enzymatic catalysis in the pocket of an enzyme, this host-guest catalyst-enzyme system allows direct proton and electron transport between two catalytic processes via NADH mimics for the monooxygenation of both cyclobutanones and thioethers. This host-guest approach, which involves the direct coupling of abiotic and biotic catalysts via a NADH-containing host, is quite promising compared to normal catalyst-enzyme systems, as it offers the key advantages of supramolecular catalysis in integrated chemical and biological synthetic sequences.
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