ArticleNature communications2020
Pushing the boundaries of optoacoustic microscopy by total impulse response characterization.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Three-dimensional photoacoustic tomography with ultrasound localization priors.Photoacoustics · 2026Article
- Dual-frequency fiber-array photoacoustic computed tomography for high-resolution deep brain imaging.Light, science & applications · 2026Article
- Effective point spread function modeling of photoacoustic remote sensing microscopy towards resolution enhancement.Photoacoustics · 2026Article
- Three-Dimensional Photoacoustic Tomography with Ultrasound Localization Priors.bioRxiv : the preprint server for biology · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Low frequency detection in clinical multispectral optoacoustic tomography.Photoacoustics · 2025Article
- Label-Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.Journal of nanobiotechnology · 2025Review
- Overdriven laser diode optoacoustic microscopy.Scientific reports · 2023Article
- Ultrawide-bandwidth high-resolution all-optical intravascular ultrasound using miniaturized photoacoustic transducer.Science advances · 2023Article
- Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography.Nature communications · 2023Article
- High-speed optical resolution photoacoustic microscopy with MEMS scanner using a novel and simple distortion correction method.Scientific reports · 2022Article
- Multiscale confocal photoacoustic dermoscopy to evaluate skin health.Quantitative imaging in medicine and surgery · 2022Article
- Detection of weak optical absorption by optical-resolution photoacoustic microscopy.Photoacoustics · 2022Article
- Label-free concurrent 5-modal microscopy (Co5M) resolves unknown spatio-temporal processes in wound healing.Communications biology · 2021Article
- In vitro optoacoustic flow cytometry with light scattering referencing.Scientific reports · 2021Article
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Spatial weight matrix in dimensionality reduction reconstruction for micro-electromechanical system-based photoacoustic microscopy.Visual computing for industry, biomedicine, and art · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to account for the spatially-dependent signal distortions induced by the acoustic detection and the time-resolved and bi-polar nature of optoacoustic signals. Correction algorithms must therefore include the spatial dependence of signals' origins and profiles in time, i.e. the four-dimensional total impulse response (TIR). However, such corrections have been so far impeded by a lack of efficient TIR-characterization methods. We introduce high-quality TIR determination based on spatially-distributed optoacoustic point sources (SOAPs), produced by scanning an optical focus on an axially-translatable 250 nm gold layer. Using a spatially-dependent TIR-correction improves the signal-to-noise ratio by >10 dB and the axial resolution by ~30%. This accomplishment displays a new performance paradigm for optoacoustic microscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.