ArticlemSystems2020
Spatial Compartmentalization of the Microbiome between the Lumen and Crypts Is Lost in the Murine Cecum following the Process of Surgery, Including Overnight Fasting and Exposure to Antibiotics.
Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Oral Nanomicelle-Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions.PLoS biology · 2026Article
- Murine Models of Klebsiella pneumoniae Gastrointestinal Infection.Current protocols · 2025Article
- Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations.Metabolites · 2025Review
- Spatial sensing as a strategy for public goods regulation by gut microbes.The ISME journal · 2025Article
- MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis.Science immunology · 2024Article
- Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Defining the Relationship of Gut Microbiota, Immunity, and Cognition in Early Life-A Narrative Review.Nutrients · 2023Review
- Issues for patchy tissues: defining roles for gut-associated lymphoid tissue in neurodevelopment and disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Single-cell analysis and spatial resolution of the gut microbiome.Frontiers in cellular and infection microbiology · 2023Review
- Disentangling host-microbiota complexity through hologenomics.Nature reviews. Genetics · 2022Review
- Editorial: Nutrients, Gut Microbiome, and Intestinal Inflammation.Frontiers in nutrition · 2022Article
- Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State.Frontiers in immunology · 2022Review
- Plumbojarosite Remediation of Soil Affects Lead Speciation and Elemental Interactions in Soil and in Mice Tissues.Environmental science & technology · 2021Article
- Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery.International journal of molecular sciences · 2020Review
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The cecum is a unique region in the mammalian intestinal tract in which the microbiome is localized to two compartments, the lumen and the crypts. The microbiome within crypts is particularly important as it is in direct contact with lining epithelial cells including stem cells. Here, we analyzed the microbiome in cecum of mice using multiple techniques including metagenomics. The lumen microbiome comprised
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.