Evidence map›Paper›PMID 32518196›Full record

ArticlemSystems2020

Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner.

Manuela-Raluca Pausan, Vassiliki Kolovetsiou-Kreiner, Gesa Lucia Richter, Tobias Madl, Elisabeth Giselbrecht, Barbara Obermayer-Pietsch, Eva-Christine Weiss, Evelyn Jantscher-Krenn, Christine Moissl-Eichinger

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Manuela-Raluca PausanInteractive Microbiome Research, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Vassiliki Kolovetsiou-KreinerDepartment of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria vassiliki.kolovetsiou@medunigraz.at evelyn.jantscher-krenn@medunigraz.at.
Gesa Lucia RichterGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Tobias MadlGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Elisabeth GiselbrechtDepartment of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
Barbara Obermayer-PietschDepartment of Internal Medicine, Division of Endocrinology and Diabetology and Department of Obstetrics and Gynecology, Endocrinology Lab Platform, Medical University of Graz, Graz, Austria.
Eva-Christine WeissDepartment of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
Evelyn Jantscher-Krenn *Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria vassiliki.kolovetsiou@medunigraz.at evelyn.jantscher-krenn@medunigraz.at.ORCID https://orcid.org/0000-0003-3568-891X
Christine Moissl-Eichinger *Interactive Microbiome Research, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Medical University of Graz · AT

Funding

Austrian Science Fund FWF I 3792Austrian Science Fund FWF P 28854
6 · The paper itself

Abstract

Preterm birth (PTB) is one of the leading causes of neonatal mortality. The causes for spontaneous PTB are multifactorial and often remain unknown. In this study, we tested the hypothesis that human milk oligosaccharides (HMOs) in blood and urine modulate the maternal urinary and vaginal microbiome and influence the risk for PTB. We analyzed the vaginal and urinary microbiome of a cross-sectional cohort of women with or without preterm labor and correlated our findings with measurements of metabolites and HMOs in urine and blood. We identified several microbial signatures, such as

Indexed as

3′-sialyllactose3′SLhuman milk oligosaccharidesinflammationmetabolitespregnancypreterm birthpreterm deliverysecretor statustocolysisurinary microbiomevaginal and urinary microbiomevaginal microbiome

Identifiers

PMID32518196
PMCPMC7289590
OpenAlexW3033503140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.