ArticlemSystems2020
Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions.
Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Real Time Pulse Chase (RTPC) In-Cell NMR Spectroscopy Reveals Critical Metabolites in Subminute Metabolism of Undifferentiated and Differentiated Human Neuronal Cells.Analytical chemistry · 2026Article
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- The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales.Annual review of microbiology · 2025Review
- Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota.Microbiology and molecular biology reviews : MMBR · 2025Review
- Vitamin BISME communications · 2025Article
- Review
- Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin BbioRxiv : the preprint server for biology · 2024Article
- Ligand cross-feeding resolves bacterial vitamin BNature · 2024Article
- Ecological dependencies and the illusion of cooperation in microbial communities.Microbiology (Reading, England) · 2024Article
- Scarcity of fixed carbon transfer in a model microbial phototroph-heterotroph interaction.The ISME journal · 2024Article
- Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12.The ISME journal · 2024Article
- A prebiotic diet modulates the oral microbiome composition and results in the attenuation of oropharyngeal candidiasis in mice.Microbiology spectrum · 2023Article
- Bacteriophage-mediated lysis supports robust growth of amino acid auxotrophs.The ISME journal · 2023Article
- Bacteriophage-mediated lysis supports robust growth of amino acid auxotrophs.bioRxiv : the preprint server for biology · 2023Article
- Classifying Interactions in a Synthetic Bacterial Community Is Hindered by Inhibitory Growth Medium.mSystems · 2022Article
- A Salvaging Strategy Enables Stable Metabolite Provisioning among Free-Living Bacteria.mSystems · 2022Article
- Prevalent emergence of reciprocity among cross-feeding bacteria.ISME communications · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microbes commonly use metabolites produced by other organisms to compete effectively with others in their environment. As a result, microbial communities are composed of networks of metabolically interdependent organisms. How these networks evolve and shape population diversity, stability, and community function is a subject of active research. But how did these metabolic interactions develop initially? In particular, how and why are metabolites such as amino acids, cofactors, and nucleobases released for the benefit of others when there apparently is no incentive to do so? Here, we discuss the hypothesis that metabolite provisioning is not itself adaptive but rather can be a natural consequence of other evolved biological functions. We outline two examples of metabolite provisioning as a by-product of other functions by considering cell lysis and regulated metabolite efflux outside their canonical roles and explore their potential to facilitate the emergence of interdependent metabolite sharing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.