Evidence map›Paper›PMID 32518158›Full record

ArticleThe Journal of biological chemistry2020

Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant

J Andrew N Alexander, Mariia Radaeva, Dustin T King, Henry F Chambers, Artem Cherkasov, Som S Chatterjee, Natalie C J Strynadka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ACS infectious diseases · 2021
    Article
  5. Inhibition of theACS infectious diseases · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

J Andrew N AlexanderDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, Canada.
Mariia RadaevaVancouver Prostate Centre, The University of British Columbia, Vancouver, British Columbia, Canada.
Dustin T KingDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, Canada.
Henry F ChambersDivision of Infectious Disease, Dept. of Medicine, San Francisco General Hospital, San Francisco, California, USA.
Artem CherkasovVancouver Prostate Centre, The University of British Columbia, Vancouver, British Columbia, Canada.
Som S ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland and Institute of Marine and Environmental Technology, Baltimore, Maryland, USA ncjs@mail.ubc.ca; schatterjee@umaryland.edu.ORCID 0000-0002-7138-4449
Natalie C J StrynadkaDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, Canada ncjs@mail.ubc.ca; schatterjee@umaryland.edu.
University of British Columbia · CASan Francisco General Hospital · USUniversity of Maryland, Baltimore · US

Funding

Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
Novel mechanism of mecA expression in Staphylococcus aureusR21AI142501 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM · 2019 to 2020
$425k
CIHRHoward Hughes Medical InstituteNIAID NIH HHS R01 AI100291NIAID NIH HHS R21 AI142501
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

Azabicyclo CompoundsBacterial Proteinsbeta-Lactamase InhibitorsCrystallography, X-RayDrug Resistance, MicrobialGene Expression Regulation, BacterialGenes, BacterialMethicillin-Resistant Staphylococcus aureusMolecular Docking SimulationProtein ConformationProtein StabilityavibactamAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsantibiotic resistanceantibioticsavibactamBlaR1crystal structurediazabicyclooctanedrug actiongene expressioninfectious diseaseMecR1methicillin-resistant Staphylococcus aureus (MRSA)molecular dockingsensor domainStaphylococcus aureus (S. aureus)X-ray crystallographyβ-lactamβ-lactam antibioticsβ-lactamase

Identifiers

PMID32518158
PMCPMC7415986
OpenAlexW3033665259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.