ArticleTrials2020
Evaluating a multicomponent program to improve hypertension control in Guatemala: study protocol for an effectiveness-implementation cluster randomized trial.
Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03504124 (Implementing a Multicomponent Intervention to Improve Hypertension Control in Central America), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementing a Multicomponent Intervention to Improve Hypertension Control in Central America
Who cites it
21 citing papers in PubMed.
- Trial
- Evaluating implementation of the HEARTS model for management of hypertension and diabetes in Guatemala: protocol for a prospective observational hybrid type 3 study.Implementation science communications · 2026Article
- Which educational interventions have been implemented to support clinical competencies among primary healthcare professionals? A scoping review.BMC primary care · 2026Article
- Prevalence of hypertension in a clinical population of primarily rural and Indigenous Guatemalan women.BMC research notes · 2026Article
- Evaluating the World Health Organization's Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala.Global heart · 2025Article
- Evaluating the World Health Organization's HEARTS Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala.medRxiv : the preprint server for health sciences · 2024Article
- Adaptation of complex interventions for people with long-term conditions: a scoping review.Translational behavioral medicine · 2024Article
- Assessing the implementation of a multi-component hypertension program in a Guatemalan under-resourced dynamic context: an application of the RE-AIM/PRISM extension for sustainability and health equity.Implementation science communications · 2024Article
- Implementing integrated hypertension and diabetes management using the World Health Organization's HEARTS model: protocol for a pilot study in the Guatemalan national primary care system.Implementation science communications · 2024Article
- Reach and effectiveness of a HEARTS hypertension pilot project in Guatemala.Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- Recommendations for Empowering Partners to Conduct Implementation Research in Latin America to Advance Global Health.Global implementation research and applications · 2023Article
- Global implementation research capacity building to address cardiovascular disease: An assessment of efforts in eight countries.PLOS global public health · 2023Article
- Applying an equity lens to assess context and implementation in public health and health services research and practice using the PRISM framework.Frontiers in health services · 2023Article
- Article
- Adults' Experiences with Type 2 Diabetes in Rural Guatemala: A Qualitative Study.Journal of health care for the poor and underserved · 2023Article
- Explanatory models of hypertension in Guatemala: recognizing the perspectives of patients, family members, health care providers and administrators, and national-level health system stakeholders.BMC public health · 2022Article
- A citation analysis and scoping systematic review of the operationalization of the Practical, Robust Implementation and Sustainability Model (PRISM).Implementation science : IS · 2022Article
- Use of the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework to guide iterative adaptations: Applications, lessons learned, and future directions.Frontiers in health services · 2022Article
- Sustaining capacity building and evidence-based NCD intervention implementation: Perspectives from the GRIT consortium.Frontiers in health services · 2022Article
- [Synthesis of evidence and recommendations: guidelines for the pharmacological treatment of arterial hypertension in adultsSíntese de evidências e recomendações: diretrizes para o tratamento farmacológico da hipertensão arterial em adultos].Revista panamericana de salud publica = Pan American journal of public health · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundHypertension is a major risk factor for cardiovascular disease (CVD). Despite advances in hypertension prevention and treatment, the proportion of patients who are aware, treated and controlled is low, particularly in low-income and middle-income countries (LMICs). We will evaluate an adapted version of a multilevel and multicomponent hypertension control program in Guatemala, previously proven effective and feasible in Argentina. The program components are: protocol-based hypertension treatment using a standardized algorithm; team-based collaborative care; health provider education; health coaching sessions; home blood pressure monitoring; blood pressure audit; and feedback.
methodsUsing a hybrid type 2 effectiveness-implementation design, we will evaluate clinical and implementation outcomes of the multicomponent program in Guatemala over an 18-month period. Through a cluster randomized trial, we will randomly assign 18 health districts to the intervention arm and 18 to enhanced usual care across five departments, enrolling 44 participants per health district and 1584 participants in total. The clinical outcomes are (1) the difference in the proportion of patients with controlled hypertension (< 130/80 mmHg) between the intervention and control groups at 18 months and (2) the net change in systolic and diastolic blood pressure from baseline to 18 months. The context-enhanced Reach, Efficacy, Adoption, Implementation, Maintenance (RE-AIM)/Practical Robust Implementation and Sustainability Model (PRISM) framework will guide the evaluation of the implementation at the level of the patient, provider, and health system. Using a mixed-methods approach, we will evaluate the following implementation outcomes: acceptability, adoption, feasibility, fidelity, adaptation, reach, sustainability, and cost-effectiveness. DISCUSSION: We will disseminate the study findings, and promote scale up and scale out of the program, if proven effective. This study will generate urgently needed data on effective, adoptable, and sustainable interventions and implementation strategies to improve hypertension control in Guatemala and other LMICs.
trial registrationClinicalTrials.gov: NCT03504124. Registered on 20 April 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.