Evidence map›Paper›PMID 32517799›Full record

ArticleBMC biology2020

Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

Federico Baldini, Johannes Hertel, Estelle Sandt, Cyrille C Thinnes, Lorieza Neuberger-Castillo, Lukas Pavelka, Fay Betsou, Rejko Krüger, Ines Thiele, NCER-PD Consortium

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 6 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 6 syntheses or guidelines pooled it, 221 citations in OpenAlex.

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  7. Article
  8. A qPCR-based approach targeting the microbial gene markerJournal of Parkinson's disease · 2026
    Article
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  12. A Functional Metabolomics Framework to Track Microbiome Drug Metabolism.bioRxiv : the preprint server for biology · 2026
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Federico BaldiniLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
Johannes HertelSchool of Medicine, National University of Ireland, Galway, Ireland.
Estelle SandtIntegrated BioBank of Luxembourg, Dudelange, Luxembourg.
Cyrille C ThinnesSchool of Medicine, National University of Ireland, Galway, Ireland.
Lorieza Neuberger-CastilloIntegrated BioBank of Luxembourg, Dudelange, Luxembourg.
Lukas PavelkaLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
Fay BetsouIntegrated BioBank of Luxembourg, Dudelange, Luxembourg.
Rejko KrügerLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
Ines ThieleLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg. ines.thiele@nuigalway.ie.
NCER-PD Consortium
Central Bank of Luxembourg · LUCentre Hospitalier de Luxembourg · LUOllscoil na Gaillimhe – University of Galway · IENational University of Ireland · IEUniversitätsmedizin Greifswald · DEUniversity of Luxembourg · LU

Funding

Fonds National de la Recherche Luxembourg FNR/P13/6682797Fonds National de la Recherche Luxembourg (LU) NCER13/BM/11264123Horizon 2020 Framework Programme 692320Horizon 2020 Framework Programme 757922Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/L023784/1Medical Research Council MR/M024962/1Parkinson's UK J-0901
6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson's Study (n = 147 typical PD cases, n = 162 controls).

resultsAll individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed by self-reporting questionnaires. Stool samples from these individuals were first analysed by 16S rRNA gene sequencing. Second, we predicted the potential secretion for 129 microbial metabolites through personalised metabolic modelling using the microbiome data and genome-scale metabolic reconstructions of human gut microbes. Our key results include the following. Eight genera and seven species changed significantly in their relative abundances between PD patients and healthy controls. PD-associated microbial patterns statistically depended on sex, age, BMI, and constipation. Particularly, the relative abundances of Bilophila and Paraprevotella were significantly associated with the Hoehn and Yahr staging after controlling for the disease duration. Furthermore, personalised metabolic modelling of the gut microbiomes revealed PD-associated metabolic patterns in the predicted secretion potential of nine microbial metabolites in PD, including increased methionine and cysteinylglycine. The predicted microbial pantothenic acid production potential was linked to the presence of specific non-motor symptoms.

conclusionOur results suggest that PD-associated alterations of the gut microbiome can translate into substantial functional differences affecting host metabolism and disease phenotype.

Indexed as

AgedCase-Control StudiesFemaleGastrointestinal MicrobiomeHumansLuxembourgMaleMiddle AgedParkinson DiseaseRNA, BacterialRNA, Ribosomal, 16SRNA, BacterialRNA, Ribosomal, 16SComputational modellingGut microbiomeMetabolic modellingParkinson’s diseaseTranssulfuration pathway

Identifiers

PMID32517799
PMCPMC7285525
OpenAlexW3033892147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.