Evidence map›Paper›PMID 32517337›Full record

ArticleNutrients2020

Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels.

Chih-Yang Huang, Kalaiselvi Sivalingam, Marthandam Asokan Shibu, Po-Hsiang Liao, Tsung-Jung Ho, Wei-Wen Kuo, Ray-Jade Chen, Cecilia-Hsuan Day, Vijaya Padma Viswanadha, Da-Tong Ju

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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  11. In Vitro Anticancer Activity of Methanolic Extract ofMolecules (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Chih-Yang HuangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Kalaiselvi SivalingamGraduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan.
Marthandam Asokan ShibuCardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Po-Hsiang LiaoDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
Tsung-Jung HoDepartment of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Cecilia-Hsuan DayDepartment of Nursing, MeiHo University, Pingtung 91202, Taiwan.
Vijaya Padma ViswanadhaDepartment of Biotechnology, Bharathiar University, Tamilnadu 641046, India.
Da-Tong JuDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
China Medical University · TWAsia University · TWBharathiar University · INMeiho University · TWTaipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWTri-Service General Hospital · TWTzu Chi Foundation · TWTzu Chi University · TW

Funding

China Medical University, Taiwan CMU103-ASIA-18Ministry of Science and Technology, Taiwan MOST-104-2410-H-029-033-MY2, MOST-106-2410-H-029 -047 -MY2
6 · The paper itself

Abstract

Mitochondrial dysfunction and disturbed mitochondrial dynamics were found to be common phenomena in the pathogenesis of Parkinson's disease (PD). Vasicinone is a quinazoline alkaloid from

Indexed as

Neuroprotective AgentsPhytotherapyAlkaloidsalpha-SynucleinAnimalsAutophagyCells, CulturedJusticiaMembrane Potential, MitochondrialMiceMitochondriaMitophagyParaquatParkinson Disease, SecondaryProtein Deglycase DJ-1Protein KinasesAlkaloidsalpha-SynucleinNeuroprotective AgentsParaquatPARK7 protein, mouseparkin proteinProtein Deglycase DJ-1Protein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesUbiquitin-Protein LigasesvasicinonemitophagyparaquatParkinson’s diseasereactive oxygen speciesvasicinoneα-synuclein

Identifiers

PMID32517337
PMCPMC7352463
OpenAlexW3033657131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.