Evidence map›Paper›PMID 32517281›Full record

ArticleDiagnostics (Basel, Switzerland)2020

NS1 Recombinant Proteins Are Efficiently Produced in

Mariana Fonseca Xisto, John Willians Oliveira Prates, Ingrid Marques Dias, Roberto Sousa Dias, Cynthia Canedo da Silva, Sérgio Oliveira de Paula

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Zika Virus Envelope Protein Domain III Produced inDiagnostics (Basel, Switzerland) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mariana Fonseca XistoDepartment of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
John Willians Oliveira PratesDepartment of Microbiology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
Ingrid Marques DiasDepartment of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
Roberto Sousa DiasDepartment of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
Cynthia Canedo da SilvaDepartment of Microbiology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
Sérgio Oliveira de PaulaDepartment of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, Brazil.
Universidade Federal de Viçosa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is one of the major diseases causing global public health concerns. Despite technological advances in vaccine production against all its serotypes, it is estimated that the dengue virus is responsible for approximately 390 million infections per year. Laboratory diagnosis has been the key point for the correct treatment and prevention of this disease. Currently, the limiting factor in the manufacture of dengue diagnostic kits is the large-scale production of the non-structural 1 (NS1) antigen used in the capture of the antibody present in the infected patients' serum. In this work, we demonstrate the production of the non-structural 1 protein of dengue virus (DENV) serotypes 1-4 (NS1-DENV1, NS1-DENV2, NS1-DENV3, and NS1-DENV4) in the methylotrophic yeast

Indexed as

denguediagnosisNS1 proteinPichia pastoris

Identifiers

PMID32517281
PMCPMC7345099
OpenAlexW3032966851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.