Evidence map›Paper›PMID 32517192›Full record

Trial reportNutrients2020

Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease.

Alvaro Alonso, Lin Y Chen, Kyle D Rudser, Faye L Norby, Mary R Rooney, Pamela L Lutsey

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-2225-8323
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Kyle D RudserDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Faye L NorbyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.ORCID 0000-0002-1975-0405
Mary R RooneyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA.ORCID 0000-0002-5607-4848
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.ORCID 0000-0002-1572-1340
University of Minnesota · USEmory University · USJohns Hopkins University · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
Mentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593k
American Heart Association 16EIA26410001American Heart Association-American Stroke Association 16EIA26410001NCATS NIH HHS UL1 TR002494NCATS NIH HHS UL1TR002494NHLBI NIH HHS K24 HL148521NHLBI NIH HHS K24HL148521NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32HL007024NHLBI NIH HHS T32 HL007779NHLBI NIH HHS T32HL007779
6 · The paper itself

Abstract

(1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log

Indexed as

Dietary SupplementsAdministration, OralBiomarkersBlood ProteinsCardiovascular DiseasesDouble-Blind MethodFemaleHumansInterleukin-1 Receptor-Like 1 ProteinMagnesiumMagnesium OxideMiddle AgedMyoglobinProteomicsTartrate-Resistant Acid PhosphataseTumor Necrosis Factor Ligand Superfamily Member 13BiomarkersBlood ProteinsIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinMagnesiumMagnesium OxideMyoglobinTartrate-Resistant Acid PhosphataseTNFSF13 protein, humanTumor Necrosis Factor Ligand Superfamily Member 13magnesiumproteomicsrandomized trial

Identifiers

PMID32517192
PMCPMC7352673
OpenAlexW3033963432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.