ArticleMolecules (Basel, Switzerland)2020
The Intriguing Effects of Substituents in the
Open access · goldAbstract read
In one paragraph
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Investigation of monoclonal antibody CSX-1004 for fentanyl overdose.Nature communications · 2023Article
- Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl-Molecules (Basel, Switzerland) · 2023Article
- Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans.Molecules (Basel, Switzerland) · 2023Article
- A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.Molecules (Basel, Switzerland) · 2022Article
- Recent Chemical and Pharmacological Developments on 14-Oxygenated-Molecules (Basel, Switzerland) · 2021Review
- Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery.Molecules (Basel, Switzerland) · 2020Article
- The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 6 institutions in 1 country.
Meining WangDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
Thomas C IrvinDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
Christine A HerdmanDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
Ramsey D HannaDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
Sergio A HassanDepartment of Health and Human Services, Center for Molecular Modeling, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
Yong-Sok LeeDepartment of Health and Human Services, Center for Molecular Modeling, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
Sophia KaskaDepartment of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045-7582, USA.
Rachel Saylor CrowleyDepartment of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045-7582, USA.
Thomas E PrisinzanoDepartment of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045-7582, USA.
Sarah L WitheyBehavioral Biology Program, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Carol A ParonisBehavioral Biology Program, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Jack BergmanBehavioral Biology Program, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Saadet InanCenter for Substance Abuse Research, Lewis Katz School of Medicine of Temple University, 3500 N. Broad St., Philadelphia, PA 19140, USA.
Ellen B GellerCenter for Substance Abuse Research, Lewis Katz School of Medicine of Temple University, 3500 N. Broad St., Philadelphia, PA 19140, USA.
Martin W AdlerCenter for Substance Abuse Research, Lewis Katz School of Medicine of Temple University, 3500 N. Broad St., Philadelphia, PA 19140, USA.
Theresa A KopajticDepartment of Health and Human Services, Psychobiology Section, Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Jonathan L KatzDepartment of Health and Human Services, Psychobiology Section, Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Aaron M ChadderdonDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
John R TraynorDepartment of Pharmacology and Edward F Domino Research Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Arthur E JacobsonDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
Kenner C RiceDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.
National Institute on Drug Abuse · USNational Institutes of Health · USHarvard University · USTemple University · USUniversity of Kansas · USUniversity of Michigan · US
Funding
Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Munir Gunes Kutlu · 2000 to 2026
$34.6MMedicinal Chemistry of Drugs Acting on Central and Peripheral Opioid ReceptorsZIADA000527 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI RICE, KENNER · 2009 to 2025
$23.2MSimulating Protein Structures, Complexes, And DynamicsZIACT000265 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI STEINBACH, PETER J · 2009 to 2020
$8.2MAllosteric Modulation of the Mu-Opioid ReceptorR37DA039997 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2015 to 2024
$6.4MIn vivo characterization of opioid biased agonistsR01DA047574 · NIDA · MCLEAN HOSPITAL · PI BERGMAN, JACK, PARONIS, CAROL A · 2019 to 2021
$809kNIDA NIH HHS P30 DA13429, DA03999, DA018151, DA035857, DA047574NIDA NIH HHS R01 DA047574NIDA NIH HHS R37 DA039997
Abstract
(-)-
Indexed as
AnimalsBinding, CompetitiveHydromorphoneHypercapniaMiceModels, MolecularProtein BindingReceptors, Opioid, deltaReceptors, Opioid, muRespiration, ArtificialSaimiriStructure-Activity RelationshipHydromorphonenorhydromorphoneReceptors, Opioid, deltaReceptors, Opioid, mu[35S]GTPgammaS assaybias factorbifunctional ligandsforskolin-induced cAMP accumulation assaysmolecular modeling & simulationMOR and DOR agonists(−)-N-phenethylnorhydromorphone analogsopioidrespiratory depressionβ-arrestin recruitment assays
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.