Evidence map›Paper›PMID 32517087›Full record

ReviewCancers2020

A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles.

Elisa Rodrigues Sousa, Eugenio Zoni, Sofia Karkampouna, Federico La Manna, Peter C Gray, Marta De Menna, Marianna Kruithof-de Julio

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Elisa Rodrigues SousaDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
Eugenio ZoniDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.ORCID 0000-0002-3070-7694
Sofia KarkampounaDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
Federico La MannaDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
Peter C GrayBiotheranostics, Inc., San Diego, CA 92121, USA.
Marta De MennaDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
Marianna Kruithof-de JulioDepartment for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
University of Bern · CHBiothera (United States) · US

Funding

KWF Kankerbestrijding UL2015-7599Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_189149Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_169352U.S. Department of Defense W81XWH-19-1-0432
6 · The paper itself

Abstract

Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating normal physiological processes, including stem cell differentiation, embryonal development, and tissue growth and remodeling, as well as pathological processes such as tumor initiation and progression. Cripto functions as a co-receptor for TGF-β ligands such as Nodal, GDF1, and GDF3. Soluble and secreted forms of Cripto also exhibit growth factor-like activity and activate SRC/MAPK/PI3K/AKT pathways. Glucose-Regulated Protein 78 kDa (GRP78) binds Cripto at the cell surface and has been shown to be required for Cripto signaling via both TGF-β and SRC/MAPK/PI3K/AKT pathways. To provide a comprehensive overview of the scientific literature related to Cripto, we performed, for the first time, a bibliometric analysis of the biological roles of Cripto as reported in the scientific literature covering the last 10 years. We present different fields of knowledge in comprehensive areas of research on Cripto, ranging from basic to translational research, using a keyword-driven approach. Our ultimate aim is to aid the scientific community in conducting targeted research by identifying areas where research has been conducted so far and, perhaps more importantly, where critical knowledge is still missing.

Indexed as

bibliometric analysisbiochemistry and molecular biologycancerCRIPTOdevelopmentexperimental medical researchTDGF-1

Identifiers

PMID32517087
PMCPMC7352664
OpenAlexW3033004399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.