Evidence map›Paper›PMID 32517086›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Impact of a Diagnosis-Centered Antibiotic Stewardship on Incident

Alain Putot, Karine Astruc, Jeremy Barben, Anca Maria Mihai, Valentine Nuss, Julien Bador, Sophie Putot, Mélanie Dipanda, Caroline Laborde, Jeremie Vovelle and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Impact of COVID-19 prevention measures onExperimental and therapeutic medicine · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Alain PutotService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Karine AstrucService d'Epidémiologie et Hygiène Hospitalière, Centre hospitalier Universitaire, 14 rue Paul Gaffarel, 21079 Dijon, France.
Jeremy BarbenService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Anca Maria MihaiService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Valentine NussService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Julien BadorService de Microbiologie, Centre hospitalier Universitaire, 14 rue Paul Gaffarel, 21079 Dijon, France.
Sophie PutotService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Mélanie DipandaService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.ORCID 0000-0002-2104-8594
Caroline LabordeService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Jeremie VovelleService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Sofia Da SilvaService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Emmanuel MazenService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
Ludwig Serge Aho GléléService d'Epidémiologie et Hygiène Hospitalière, Centre hospitalier Universitaire, 14 rue Paul Gaffarel, 21079 Dijon, France.
Patrick ManckoundiaService de Médecine Interne Gériatrie, Hôpital de Champmaillot, Centre hospitalier Universitaire, 2 rue Jules Violle, 21079 Dijon, France.
CHU Dijon Bourgogne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2015, a major increase in incident hospital-onset Clostridioides difficile infections (HO-CDI) in a geriatric university hospital led to the implementation of a diagnosis-centered antibiotic stewardship program (ASP). We aimed to evaluate the impact of the ASP on antibiotic consumption and on HO-CDI incidence. The intervention was the arrival of a full-time infectiologist in the acute geriatric unit in May 2015, followed by the implementation of new diagnostic procedures for infections associated with an antibiotic withdrawal policy. Between 2015 and 2018, the ASP was associated with a major reduction in diagnoses for inpatients (23% to 13% for pneumonia, 24% to 13% for urinary tract infection), while median hospital stays and mortality rates remained stable. The reduction in diagnosed bacterial infections was associated with a 45% decrease in antibiotic consumption in the acute geriatric unit. HO-CDI incidence also decreased dramatically from 1.4‱ bed-days to 0.8‱ bed-days in the geriatric rehabilitation unit. The ASP focused on reducing the overdiagnosis of bacterial infections in the acute geriatric unit was successfully associated with both a reduction in antibiotic use and a clear reduction in the incidence of HO-CDI in the geriatric rehabilitation unit.

Indexed as

acute infectionagedantibioticClostridioides difficileclostridiumdiagnosticstewardship

Identifiers

PMID32517086
PMCPMC7345193
OpenAlexW3033058369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.