Evidence map›Paper›PMID 32517031›Full record

ArticleNutrients2020

Allithiamine Alleviates Hyperglycaemia-Induced Endothelial Dysfunction.

Attila Biró, Arnold Markovics, Mónika Éva Fazekas, Gábor Fidler, Gábor Szalóki, Melinda Paholcsek, János Lukács, László Stündl, Judit Remenyik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Development of Novel 3D Spheroids for Discrete Subaortic Stenosis.Cardiovascular engineering and technology · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Attila BiróInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary.
Arnold MarkovicsInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary.
Mónika Éva FazekasInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary.
Gábor FidlerDepartment of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Gábor Szalókist Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary.
Melinda PaholcsekDepartment of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
János LukácsDepartment of Obstetrics and Gynaecology, University of Debrecen, H-4032 Debrecen, Hungary.
László StündlInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary.
Judit RemenyikInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary.
University of Debrecen · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus-related morbidity and mortality is a rapidly growing healthcare problem, globally. Several nutraceuticals exhibit potency to target the pathogenesis of diabetes mellitus. The antidiabetic effects of compounds of garlic have been extensively studied, however, limited data are available on the biological effects of a certain garlic component, allithiamine. In this study, allithiamine was tested using human umbilical cord vein endothelial cells (HUVECs) as a hyperglycaemic model. HUVECs were isolated by enzymatic digestion and characterized by flow cytometric analysis using antibodies against specific marker proteins including CD31, CD45, CD54, and CD106. The non-cytotoxic concentration of allithiamine was determined based on MTT, apoptosis, and necrosis assays. Subsequently, cells were divided into three groups: incubating with M199 medium as the control; or with 30 mMol/L glucose; or with 30 mMol/L glucose plus allithiamine. The effect of allithiamine on the levels of advanced glycation end-products (AGEs), activation of NF-κB, release of pro-inflammatory cytokines including IL-6, IL-8, and TNF-α, and H

Indexed as

Anti-Inflammatory AgentsAntioxidantsPhytotherapyCytokinesEndothelium, VascularGarlicGlycation End Products, AdvancedHumansHuman Umbilical Vein Endothelial CellsHyperglycemiaInflammation MediatorsNF-kappa BOxidative StressThiamineTransketolaseallithiamineAnti-Inflammatory AgentsAntioxidantsCytokinesGlycation End Products, AdvancedInflammation MediatorsNF-kappa BThiamineTransketolaseadvanced glycation end-productsallithiaminecytokinesgarlichyperglycaemia

Identifiers

PMID32517031
PMCPMC7352751
OpenAlexW3033482684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.