Evidence map›Paper›PMID 32517029›Full record

ArticleInternational journal of molecular sciences2020

Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo.

Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu, An-Rong Lee, Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien Chang and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Angiotensin II and dengue.Archives of virology · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Fu-Kai ChuangPenghu Branch of Tri-Service General Hospital, Penghu 88056, Taiwan.
Ching-Len LiaoDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.
Ming-Kuan HuSchool of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
Yi-Lin ChiuDepartment of Biochemistry, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-1827-6924
An-Rong LeeSchool of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
Shih-Ming HuangDepartment of Biochemistry, National Defense Medical Center, Taipei 11490, Taiwan.
Yu-Lung ChiuSchool of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
Pei-Ling TsaiDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.
Bo-Cyuan SuDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.
Tsung-Hsien ChangDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.ORCID 0000-0003-4806-7864
Chang-Chi LinDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.
Chih-Chin ShihDepartment of Pharmacology, National Defense Medical Center, Taipei 11490, Taiwan.
Li-Chen YenDepartment of Microbiology and Immunology, National Defense Medical Center, 161, Sec. 6, Min-Chuan E. Road, Neihu, Taipei 11490, Taiwan.ORCID 0000-0002-1891-5546
National Defense Medical Center · TWNational Health Research Institutes · TWTri-Service General Hospital · TW

Funding

Ministry of National Defense Medical Affairs Bureau MAB-107-078, MAB-108-054 and MAB-109-060Ministry of Science and Technology, Taiwan MOST 105-2628-B-016-002-MY2Tri-Service General Hospital TSGH-PH-106-02 and TSGH-PH-107-01
6 · The paper itself

Abstract

Dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne flaviviruses that cause severe illness after infection. Currently, there are no specific or effective treatments against DENV and ZIKV. Previous studies have shown that tyrosine kinase activities and signal transduction are involved in flavivirus replication, suggesting a potential therapeutic strategy for DENV and ZIKV. In this study, we found that compound

Indexed as

AfatinibAnimalsAntiviral AgentsCells, CulturedDengueDengue VirusDose-Response Relationship, DrugErbB ReceptorsHEK293 CellsHumansInhibitory Concentration 50MiceProtein Kinase InhibitorsSignal TransductionVirus ReplicationZika VirusAfatinibAntiviral AgentsErbB ReceptorsProtein Kinase Inhibitorsanti-viral drugsdengue virusflavivirustyrosine kinase inhibitorsZika virus

Identifiers

PMID32517029
PMCPMC7312370
OpenAlexW3033474127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.