Evidence map›Paper›PMID 32516861›Full record

Observational studyGeriatrics & gerontology international2020

Clinical characteristics and prognostic factors in COVID-19 patients aged ≥80 years.

Marcello Covino, Giuseppe De Matteis, Michele Santoro, Luca Sabia, Benedetta Simeoni, Marcello Candelli, Veronica Ojetti, Francesco Franceschi

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Geriatrics & gerontology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 7 pooled it
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 7 syntheses or guidelines pooled it, 147 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marcello CovinoEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-6709-2531
Giuseppe De MatteisDepartment of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Michele SantoroEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Luca SabiaEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Benedetta SimeoniEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Marcello CandelliEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Veronica OjettiEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Francesco FranceschiEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of the present study was to describe the clinical presentation of patients aged ≥80 years with coronavirus disease 2019 (COVID-19), and provide insights regarding the prognostic factors and the risk stratification in this population.

methodsThis was a single-center, retrospective, observational study, carried out in a referral center for COVID-19 in central Italy. We reviewed the clinical records of patients consecutively admitted for confirmed COVID-19 over a 1-month period (1-31 March 2020). We excluded asymptomatic discharged patients. We identified risk factors for death, by a uni- and multivariate Cox regression analysis. To improve model fitting and hazard estimation, continuous parameters where dichotomized by using Youden's index.

resultsOverall, 69 patients, aged 80-98 years, met the inclusion criteria and were included in the study cohort. The median age was 84 years (82-89 years is interquartile range); 37 patients (53.6%) were men. Globally, 14 patients (20.3%) presented a mild, 30 (43.5%) a severe and 25 (36.2%) a critical COVID-19 disease. A total of 23 (33.3%) patients had died at 30 days' follow up. Multivariate Cox regression analysis showed that severe dementia, pO

conclusionsThe present data suggest that risk of death could be not age dependent in patients aged ≥80 years, whereas severe dementia emerged is a relevant risk factor in this population. Severe COVID-19, as expressed by elevated lactate dehydrogenase and low oxygen saturation at emergency department admission, is associated with a rapid progression to death in these patients. Geriatr Gerontol Int 2020; ••: ••-••.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralAged, 80 and overBetacoronavirusCOVID-19Critical IllnessDementiaFemaleHumansHypoxiaItalyL-Lactate DehydrogenaseMaleMortalityPrognosisL-Lactate DehydrogenaseCOVID-19dementiaolder adultsprognostic factors

Identifiers

PMID32516861
PMCPMC7300699
OpenAlexW3033366431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.