Evidence map›Paper›PMID 32516748›Full record

ArticlePregnancy hypertension2020

Latency of preterm hypertensive disorders of pregnancy and subsequent cardiovascular complications.

Joshua I Rosenbloom, Dustin Stwalley, Kathryn J Lindley, D Michael Nelson, Margaret A Olsen, Molly J Stout

Open access · greenAbstract read
In one paragraph

Article in Pregnancy hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  9. Peripartum considerations for women with cardiac disease.Current opinion in anaesthesiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Joshua I RosenbloomDepartment of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, USA; Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address: rosenbloomj@wustl.edu.
Dustin StwalleyDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine in St. Louis, USA.
Kathryn J LindleyCardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, USA.
D Michael NelsonDepartment of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, USA.
Margaret A OlsenDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine in St. Louis, USA.
Molly J StoutDepartment of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, USA.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WASHINGTON UNIVERSITY COMPARATIVE EFFECTIVENESS ADMINISTRATIVE DATA REPOSITORYR24HS019455 · AHRQ · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$969k
AHRQ HHS R24 HS019455NCATS NIH HHS UL1 TR002345
6 · The paper itself

Abstract

objectivesTo test the hypothesis that increasing latency from diagnosis to delivery in patients with preterm hypertensive disorders of pregnancy is associated with an increased maternal risk of cardiovascular admission after delivery. STUDY

designRetrospective cohort from the IBM MarketScan® Commercial Database from 2006 to 2016. Patients age 15-45 years with a preterm delivery complicated by a hypertensive disorder of pregnancy, at least 6 months of continuous insurance coverage prior to delivery and at least 365 days of coverage post-delivery were included.

main outcome measuresHospital readmission after delivery for a composite of acute cardiovascular events (cardiomyopathy, heart failure, cardiac arrest, myocardial infarction) or cerebrovascular events. Cox proportional hazards were used to estimate the risk of the primary outcome for each week of latency from diagnosis to delivery.

resultsThere were 34,989 women in the study with a median follow-up of 2.57 years (IQR 1.66 to 1.54 years) with a median time from diagnosis to delivery of three days (IQR 0 to 14 days). An increasing time from diagnosis to delivery was associated with an increased risk of an acute cardiovascular event (adjusted HR 1.06, 95% CI 1.01, 1.11 per week), in models adjusted for maternal comorbidities and demographic factors. Later gestational age at diagnosis was associated with a decreased risk of maternal cardiovascular admission after delivery (aHR 0.94, 95% CI 0.91, 0.98 for each week increase in gestational age).

conclusionsProlonging expectant management of preterm hypertensive disorders of pregnancy is associated with an increased risk of maternal cardiovascular disease after delivery.

Indexed as

AdultBenzopyransCardiovascular DiseasesDatabases, FactualFemaleGestational AgeHumansPatient ReadmissionPostpartum PeriodPre-EclampsiaPregnancyRetrospective StudiesRisk FactorsBenzopyranstimefuroneCardiovascular diseaseExpectant managementHypertensive disorders of pregnancyPreterm

Identifiers

PMID32516748
PMCPMC7548294
OpenAlexW3031864191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.