ArticleCurrent biology : CB2020
Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- Molecular characterization of the sea lamprey retina illuminates the evolutionary origin of retinal cell types.Nature communications · 2024Article
- The vertebrate retina: a window into the evolution of computation in the brain.Current opinion in behavioral sciences · 2024Review
- Birds multiplex spectral and temporal visual information via retinal On- and Off-channels.Nature communications · 2023Article
- Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Vision: Life on the dark side.Current biology : CB · 2022Article
- S-cone circuits in the primate retina for non-image-forming vision.Seminars in cell & developmental biology · 2022Review
- A hyperpolarizing rod bipolar cell in the sea lamprey, Petromyzon marinus.The Journal of experimental biology · 2022Article
- Temporal vision: measures, mechanisms and meaning.The Journal of experimental biology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ellis et al. show that retinal ON and OFF bipolar cells, and the novel metabotropic glutamate receptors of ON bipolar-cell dendrites, are both present in lamprey. They conclude that the fundamental organizing principle of separate ON and OFF pathways first appeared in the vertebrate visual system over 500 million years ago in the late Cambrian.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.