Evidence map›Paper›PMID 32516575›Full record

ArticleCell metabolism2020

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

Nelson M LaMarche, Harry Kane, Ayano C Kohlgruber, Han Dong, Lydia Lynch, Michael B Brenner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  4. Article
  5. Review
  6. Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Immune system influence on physiology.Science (New York, N.Y.) · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nelson M LaMarcheDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA; Program in Immunology, Harvard Medical School, Boston, MA, USA.
Harry KaneTrinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Ayano C KohlgruberDivision of Genetics, Brigham and Women's Hospital, Boston, MA, USA.
Han DongDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA, USA.
Lydia LynchTrinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland; Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Michael B BrennerDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA; Program in Immunology, Harvard Medical School, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: mbrenner@research.bwh.harvard.edu.
Harvard University · USTrinity College Dublin · IEBrigham and Women's Hospital · US

Funding

Regulatory iNKT Cells Suppress Inflammation and Drive ThermogenesisR01AI113046 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2014 to 2023
$3.9M
Supplement: Immunometabolic and epigenetic effects of obesity on innate immune surveillance in cancerR01AI134861 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LYNCH, LYDIA · 2018 to 2022
$2.9M
Identification of Adipose Tissue Factors that Induce Regulatory iNKT CellsF31AI138353 · NIAID · HARVARD MEDICAL SCHOOL · PI LAMARCHE, NELSON MARTIN · 2018 to 2020
$93k
NIAID NIH HHS F31 AI138353NIAID NIH HHS R01 AI113046NIAID NIH HHS R01 AI134861
6 · The paper itself

Abstract

Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1

Indexed as

Adipose TissueAnimalsEndoplasmic Reticulum StressHomeostasisInterferon-gammaInterleukin-10MiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsIFNG protein, mouseIL10 protein, mouseInterferon-gammaInterleukin-10adipose tissueER stressinflammationiNKT cellslipidsmacrophagesNK cellsobesity

Identifiers

PMID32516575
PMCPMC8234787
OpenAlexW3033964929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.