Evidence map›Paper›PMID 32516574›Full record

ArticleNeuron2020

Magnetoelectric Materials for Miniature, Wireless Neural Stimulation at Therapeutic Frequencies.

Amanda Singer, Shayok Dutta, Eric Lewis, Ziying Chen, Joshua C Chen, Nishant Verma, Benjamin Avants, Ariel K Feldman, John O'Malley, Michael Beierlein and 2 more

Abstract read
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Magnetoelectric BaTiOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Aerosol Jet Printing for Neuroprosthetic Device Development.Bioengineering (Basel, Switzerland) · 2025
    Review
  14. Article
  15. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Amanda SingerApplied Physics Program, Rice University, Houston, TX 77005, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Shayok DuttaDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Eric LewisDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Ziying ChenDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Joshua C ChenDepartment of Bioengineering, Rice University, Houston, TX 77005, USA.
Nishant VermaDepartment of Bioengineering, Rice University, Houston, TX 77005, USA.
Benjamin AvantsDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Ariel K FeldmanDepartment of Computer Science, Rice University, Houston, TX 77005, USA; Department of Cognitive Science, Rice University, Houston, TX 77005, USA.
John O'MalleyDepartment of Neurobiology and Anatomy, McGovern Medical School at UTHealth, Houston, TX 77030, USA.
Michael BeierleinDepartment of Neurobiology and Anatomy, McGovern Medical School at UTHealth, Houston, TX 77030, USA.
Caleb KemereDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Jacob T RobinsonApplied Physics Program, Rice University, Houston, TX 77005, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: jtrobinson@rice.edu.

Funding

Development of a Wireless Endovascular Nerve Stimulator for Treatment of Refractory Neuropathic PainU18EB029353 · NIBIB · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAN, PETER TZE MAN, ROBINSON, JACOB T. · 2019 to 2019
$2.3M
Fluidic microdrives for minimally invasive actuation of flexible electrodesR21EY028397 · NEI · RICE UNIVERSITY · PI ROBINSON, JACOB T. · 2017 to 2018
$475k
NEI NIH HHS R21 EY028397NIBIB NIH HHS U18 EB029353
6 · The paper itself

Abstract

A major challenge for miniature bioelectronics is wireless power delivery deep inside the body. Electromagnetic or ultrasound waves suffer from absorption and impedance mismatches at biological interfaces. On the other hand, magnetic fields do not suffer these losses, which has led to magnetically powered bioelectronic implants based on induction or magnetothermal effects. However, these approaches have yet to produce a miniature stimulator that operates at clinically relevant high frequencies. Here, we show that an alternative wireless power method based on magnetoelectric (ME) materials enables miniature magnetically powered neural stimulators that operate up to clinically relevant frequencies in excess of 100 Hz. We demonstrate that wireless ME stimulators provide therapeutic deep brain stimulation in a freely moving rodent model for Parkinson's disease and that these devices can be miniaturized to millimeter-scale and fully implanted. These results suggest that ME materials are an excellent candidate to enable miniature bioelectronics for clinical and research applications.

Indexed as

Implantable NeurostimulatorsAnimalsDeep Brain StimulationEquipment DesignHumansWireless Technologyfully implantedmagnetoelectricminiatureneural stimulation

Identifiers

PMID32516574
PMCPMC7818389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.