Observational studyAmerican journal of respiratory and critical care medicine2020
Incidence and Outcome of Subclinical Acute Kidney Injury Using penKid in Critically Ill Patients.
Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07025629 (Dapagliflozin for Cardio-renal Protection After ICU Discharge), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dapagliflozin for Cardio-renal Protection After ICU Discharge: A Prospective, Randomized, Double Blinded, Multicenter Study: "DAPA-ICU Trial"
PMID 30424892PMID 32877652PMID 32492305PMID 31009585PMID 30045823PMID 29347987PMID 27391020other papers from this trial
Open the trial in the graphWho cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis -results of a patient-level meta-analysis.Critical care (London, England) · 2026Pooled it
- Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis.Frontiers in medicine · 2024Pooled it
- Proenkephalin A 119-159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial.Critical care (London, England) · 2022Trial
- Machine-learning algorithms identifies sTREM1 has a key biomarker for outcome prediction in critically ill.Critical care (London, England) · 2026Observational
- Biomarker-Based Diagnosis and Risk Stratification in Sepsis-Associated Acute Kidney Injury: From Molecular Mechanisms to Multimarker Panels.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- Biomarker-driven risk stratification and early intervention in acute kidney injury: a comprehensive review from early warning to clinical response.Frontiers in medicine · 2026Review
- Antiproteinuric effect of dapagliflozin attenuates tubule-interstitial injury development in subclinical acute kidney injury animal model.Frontiers in pharmacology · 2026Article
- Evaluation of a Novel Biomarker Panel for Acute Kidney Injury Following Endovascular Aortic Repair.International journal of molecular sciences · 2025Article
- Article
- Diffusion kurtosis imaging and arterial spin labeling MRI for assessment of post-contrast acute kidney injury risk in rats with subclinical kidney injury.BMC nephrology · 2025Article
- Proenkephalin A 119-159 as an early biomarker of acute kidney injury in complex endovascular aortic repair: an explorative single-center cross-sectional study with the utilization of two measurement methods.Perioperative medicine (London, England) · 2025Article
- Biomarkers in acute kidney injury settings to predict interventions and outcomes: the MARKISIO study.Critical care (London, England) · 2025Article
- Markers of Kidney Injury: Proenkephalin A and Uromodulin, but Not Dickkopf-3, Are Elevated in Patients After Hematopoietic Stem Cell Transplantation.International journal of molecular sciences · 2025Article
- Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury.Critical care (London, England) · 2025Article
- Implementation and One-Year Evaluation of Proenkephalin A in Critical Care.International journal of molecular sciences · 2025Article
- Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score.European heart journal · 2025Article
- Proenkephalin A 119-159 in Kidney Transplantation: A Novel Biomarker for Superior Tracking of Graft Function Trajectories.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- The promise of biomarkers: precision medicine will pave a roadmap for pediatric acute kidney injury management in critically ill children.Intensive care medicine. Paediatric and neonatal · 2025Review
- Proenkephalin A 119-159 in Perioperative and Intensive Care-A Promising Biomarker or Merely Another Option?Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
28 authors at 14 institutions in 4 countries.
François DépretDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0001-9988-4317
Alexa HollingerDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0001-6799-1652
Alain CariouMedical Intensive Care Unit, Cochin University Hospital, AP-HP, Paris, France.
Nicolas DeyeUMR-S942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, Paris, France.
Antoine Vieillard-BaronIntensive Care Unit, University Hospital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.
Marie-Céline FournierDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Samir JaberIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, Montpellier, France.
Charles DamoiselDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Qin LuMultidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, La Pitié-Salpétrière Hospital, AP-HP, Paris, France.
Xavier MonnetMedical Intensive Care Unit, Bicêtre Hospital, Paris-Sud University Hospitals, Le Kremlin-Bicêtre, France.
Isabelle RennuitDepartment of Anesthesiology and Critical Care, Beaujon Hospital, AP-HP, Clichy, France.
Michael DarmonParis University, Paris, France.
Marc LeoneAPHM, Department of Anesthesiology and Critical Care Medicine, Marseille, France.
Bertrand GuidetPierre and Marie Curie University, Paris 6, Paris, France.
Romain SonnevilleParis University, Paris, France.ORCID 0000-0003-0245-309X
Philippe MontraversParis University, Paris, France.
Sébastien Pili-FlouryDepartment of Anesthesiology and Intensive Care Medicine, Besançon University Hospital, EA 3920, Besançon, France.
Jean-Yves LefrantDepartment of Anesthesiology, Critical Care, Emergency and Pain Medicine, Nimes University Hospital, Nîmes, France.
Jacques DuranteauDepartment of Anesthesiology and Critical Care, Paris-Sud, AP-HP, Le Kremlin-Bicêtre, France.
Pierre-François LaterreDepartment of Critical Care Medicine, Saint Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
Nicolas BrechotINSERM, U833, Angiogenesis, Embryogenesis and Pathology Laboratory, Collège de France, Paris, France.
Haikel OueslatiDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Bernard CholleyDepartment of Anesthesiology and Intensive Care, European Hospital Georges Pompidou University Hospital, AP-HP, Paris, France.
Joachim Strucksphingotec GmbH, Hennigsdorf, Germany; and.
Oliver Hartmannsphingotec GmbH, Hennigsdorf, Germany; and.
Alexandre MebazaaDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0001-8715-7753
Etienne GayatDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, Saint Louis-Lariboisière University Hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0002-3334-3849
Matthieu LegrandParis University, Paris, France.ORCID 0000-0001-9788-5316
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRAix-Marseille Université · FRCentre Hospitalier Universitaire de Besançon · FRCliniques Universitaires Saint-Luc · BEDélégation Paris 5 · FRHôpital Beaujon · FRHôpital Cochin · FRHôpital Saint Eloi · FRUniversité Claude Bernard Lyon 1 · FRUniversité de Montpellier · FRUniversité Paris-Sud · FRUniversity of California, San Francisco · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acute Kidney InjuryAgedBiomarkersCohort StudiesCritical IllnessDecision MakingEnkephalinsEuropeFemaleHumansIncidenceMaleMiddle AgedProspective StudiesProtein PrecursorsRisk FactorsBiomarkersEnkephalinsProtein Precursorsacute kidney injurybiomarkerpenKidproenkephalinrenal recovery
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT07025629ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.