ArticleThe Pediatric infectious disease journal2020
Differences in Growth of HIV-exposed Uninfected Infants in Ethiopia According to Timing of In-utero Antiretroviral Therapy Exposure.
Article in The Pediatric infectious disease journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Placenta models for HIV-1-ART-nicotine comorbidity research: advances and remaining challenges.Cell death discovery · 2026Review
- Higher infant dietary diversity is associated with a reduced risk of stunting in the second year among a longitudinal cohort of HIV-unexposed and HIV-exposed but uninfected Kenyan children.Public health nutrition · 2026Article
- The impact of dolutegravir on the growth of HIV-exposed uninfected infants: an observational cohort study in rural Tanzania.EClinicalMedicine · 2026Article
- Differences in growth trajectories in breastfed HIV-exposed uninfected and HIV-unexposed infants in Kenya: An observational cohort study.PLoS medicine · 2025Observational
- Growth Patterns of HIV-Exposed and -Unexposed Infants in African Countries: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Poorer Longitudinal Growth Among HIV Exposed Compared With Unexposed Infants in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Review
- Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants.Frontiers in immunology · 2025Article
- Phenotypic characterization of NK cells in 5-year-old children exposed to maternal HIV and antiretroviral therapy in early-life.BMC immunology · 2024Article
- Diminished placental Factor XIIIA1 expression associates with pre-conception antiretroviral treatment and preterm birth in pregnant people living with HIV.bioRxiv : the preprint server for biology · 2024Article
- Article
- Prevalence and associated factors of enamel developmental defects among Nigerian children with perinatal HIV exposure.The Journal of clinical pediatric dentistry · 2023Article
- Risk factors for stunting in children who are HIV-exposed and uninfected after Option B+ implementation in Malawi.Maternal & child nutrition · 2023Article
- Impact of antenatal antiretroviral drug exposure on the growth of children who are HIV-exposed uninfected: the national South African Prevention of Mother to Child Evaluation cohort study.BMC infectious diseases · 2022Article
- Growth patterns of infants with in- utero HIV and ARV exposure in Cape Town, South Africa and Lusaka, Zambia.BMC public health · 2022Observational
- No Difference in Growth Outcomes up to 24 Months of Age by Duration of Exposure to Maternal Antiretroviral Therapy Among Children Who Are HIV-Exposed and Uninfected in Malawi.Frontiers in pediatrics · 2022Article
- A comparison of weight gain between HIV exposed uninfected and HIV unexposed uninfected infants who received KMC at Chris Hani Baragwanath Academic Hospital.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
Abstract
backgroundThere are concerns about the adverse effect of in-utero exposure to antiretroviral therapy (ART) on the growth of HIV exposed-uninfected (HEU) infants. We compared growth of HEU-infants according to the timing and type of ART exposure.
methodsA retrospective cohort study was conducted by abstracting clinical data from HIV-infected mothers and HEU-infants in Addis Ababa, Ethiopia between February 2013 and October 2016. Mixed-effects linear models were used to compare changes in weight and length and cox proportional hazard models were used to evaluate stunting (length-for-age z score <-2.0) and underweight (weight-for-age z score <-2.0).
resultsA total of 624 HEU-infants were included in the analyses. Infants exposed to ART from conception had a lower rate of change in length [β = -0.54, 95% confidence interval (CI): -1.00 to -0.08] the first 3 months of life, as compared with infants exposed from late pregnancy. Risk of stunting was 51.9 per 100 person-years and risk of underweight was 26.7 per 100 person-years. Exposure to ART from conception was associated with a higher rate of stunting as compared with exposure from late pregnancy (adjusted hazard ratio = 1.95, 95% CI: 1.27-2.99). Infants born to mothers with advanced disease had a higher incidence of underweight compared with infants born to mothers with early-stage disease adjusted hazard ratio = 1.99, 95% CI: 1.32-3.03).
conclusionsIn HEU-infants, exposure to ART from conception was associated with decrease growth during early infancy and higher incidence of stunting compared with treatment exposure later in pregnancy. Close monitoring of HEU-infants' growth and prompt nutritional intervention is essential.
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