Evidence map›Paper›PMID 32516191›Full record

ReviewCurrent sports medicine reports2020

Role of Mechanical Loading for Platelet-Rich Plasma-Treated Achilles Tendinopathy.

Alyssa Neph, Allison Schroeder, Keelen R Enseki, Peter A Everts, James H-C Wang, Kentaro Onishi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current sports medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyssa NephDepartment of Physical Medicine and Rehabilitation at University of Pittsburgh Medical Center, Pittsburgh, PA.
Allison SchroederDepartment of Physical Medicine and Rehabilitation at University of Pittsburgh Medical Center, Pittsburgh, PA.
Keelen R EnsekiUniversity of Pittsburgh Medical Center Centers for Rehab Services, Pittsburgh, PA.
Peter A EvertsScientific and Research Department at Gulf Coast Biologics, Fort Myers, FL.
James H-C WangDepartment of Orthopedic Surgery at University of Pittsburgh School of Medicine, Pittsburgh, PA.
Kentaro Onishi

Funding

The role of TSCs in the degenerative tendinopathy induced by mechanical loadingR01AR065949 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2015 to 2019
$1.7M
HMGB1 Mediates the Onset of Loading-Induced Tendon InjuryR21AR070340 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2016 to 2017
$374k
NIAMS NIH HHS R01 AR065949NIAMS NIH HHS R21 AR070340
6 · The paper itself

Abstract

There is no consensus on the optimal rehabilitation protocol after platelet-rich plasma (PRP) treatment for tendinopathy despite basic science studies showing the critical role of mechanical loading in the restoration of tendon structure and function posttreatment. In this article, we will review tendon mechanobiology, platelet biology, and review levels I and II Achilles tendon clinical studies paying particular attention to the role of mechanical loading in rehabilitation of injured tendons. Animal studies emphasize the synergistic effect of mechanical tendon loading and PRP to treat tendon injury while clinical studies described minimal details on loading protocols.

Indexed as

Platelet-Rich PlasmaAchilles TendonAnimalsCombined Modality TherapyExercise TherapyHumansTendinopathy

Identifiers

PMID32516191
PMCPMC8898381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.