Evidence map›Paper›PMID 32515944›Full record

ArticleACS nano2020

Polymersomes Eradicating Intracellular Bacteria.

Federico Fenaroli, James D Robertson, Edoardo Scarpa, Virginia M Gouveia, Claudia Di Guglielmo, Cesare De Pace, Philip M Elks, Alessandro Poma, Dimitrios Evangelopoulos, Julio Ortiz Canseco and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Supramolecular Aggregates: Hardness Plus Softness.Molecules (Basel, Switzerland) · 2021
    Review
  12. Zebrafish: An Attractive Model to StudyPharmaceuticals (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Engineering Polymeric Nanosystems against Oral Diseases.Molecules (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 4 countries.

Federico FenaroliDepartment of Biosciences, University of Oslo, 0371 Oslo, Norway.ORCID 0000-0002-9060-8786
James D RobertsonDepartment of Biomedical Science, University of Sheffield, S10 2TN Sheffield, U.K.
Edoardo ScarpaDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.
Virginia M GouveiaDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.
Claudia Di GuglielmoInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Cesare De PaceDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.
Philip M ElksDepartment of Biomedical Science, University of Sheffield, S10 2TN Sheffield, U.K.
Alessandro PomaDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.
Dimitrios EvangelopoulosDepartment of Clinical Microbiology, University College London, Royal Free Hospital, NW3 2PF London, U.K.
Julio Ortiz CansecoDepartment of Clinical Microbiology, University College London, Royal Free Hospital, NW3 2PF London, U.K.
Tomasz K PrajsnarThe Florey Institute, University of Sheffield, S10 2TN Sheffield, U.K.
Helen M MarriottDepartment of Infection, Immunity, and Cardiovascular Disease, University of Sheffield Medical School, S10 2JF Sheffield, U.K.
David H DockrellDepartment of Infection, Immunity, and Cardiovascular Disease, University of Sheffield Medical School, S10 2JF Sheffield, U.K.
Simon J FosterThe Florey Institute, University of Sheffield, S10 2TN Sheffield, U.K.
Timothy D McHughDepartment of Clinical Microbiology, University College London, Royal Free Hospital, NW3 2PF London, U.K.
Stephen A RenshawThe Bateson Centre, University of Sheffield, Firth Court, S10 2TN Sheffield, U.K.
Josep Samitier MartíInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Giuseppe BattagliaDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.ORCID 0000-0003-3349-6770
Loris RizzelloDepartment of Chemistry, University College London, WC1H 0AJ London, U.K.
University of Sheffield · GBThe Royal Free Hospital · GBUniversity College London · GBBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESEastman Dental Hospital · GBEngineering and Physical Sciences Research Council · GBInstitució Catalana de Recerca i Estudis Avançats · ESInstitute for Bioengineering of Catalonia · ESUniversity of Milan · ITUniversity of Oslo · NO

Funding

Medical Research Council MR/N02995X/1Wellcome Trust 105570
6 · The paper itself

Abstract

Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection. One of the most infamous is the bacteria that cause tuberculosis (TB), which is the most pandemic and one of the deadliest diseases, with one-third of the world's population infected and an average of 1.8 million deaths/year worldwide. Here we demonstrate the effective targeting and intracellular delivery of antibiotics to infected macrophages both

Indexed as

Mycobacterium tuberculosisTuberculosisAnimalsHumansMacrophagesMonocytesZebrafishdrug deliveryintracellular pathogenspolymersomestuberculosiszebrafish

Identifiers

PMID32515944
PMCPMC7618071
OpenAlexW3033305593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.