Evidence map›Paper›PMID 32515897›Full record

ArticleAnnals of clinical and translational neurology2020

The CSF Levels of Neutrophil-Related Chemokines in Patients with Neuromyelitis Optica.

Zhuhe Liu, Jinyu Chen, Zhanhang Wang, Yao Wang, Dong Zheng, Honghao Wang, Yu Peng

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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  5. Induction of immune tolerance in NMOSD and MOGAD.Therapeutic advances in neurological disorders · 2025
    Review
  6. Article
  7. Blood-Brain Barrier Disruption in Neuroimmunological Disease.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhuhe LiuDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jinyu ChenDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhanhang WangDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.
Yao WangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Dong ZhengDepartment of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Honghao WangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-1215-6219
Yu PengDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNFirst Affiliated Hospital of Guangzhou Medical University · CNGuangdong 999 Brain Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathologic findings showed that neutrophils played an important role in the pathogenesis of NMO. This study aims to investigate the CSF levels of neutrophil-related chemokines in NMO. CXCL1, CXCL5, and CXCL7 were measured in 95 patients with NMO, 15 patients with MS, 18 patients with GFAP astrocytopathy, and 16 controls. The CSF level of CXCL1, CXCL5, and CXCL7 was significantly elevated in the NMO group but not correlated with the patient clinical severity. Besides, the CSF CXCL1, CXCL5, and CXCL7 could act as biomarkers to distinguish NMO from MS with good reliability, especially the CXCL7.

Indexed as

Neutrophil ActivationAdultbeta-ThromboglobulinChemokine CXCL1Chemokine CXCL5FemaleHumansMaleMiddle AgedNeuromyelitis OpticaSeverity of Illness Indexbeta-ThromboglobulinChemokine CXCL1Chemokine CXCL5CXCL1 protein, humanCXCL5 protein, humanPPBP protein, humanCXCL1CXCL5CXCL7neuromyelitis opticaneutrophil-related chemokines

Identifiers

PMID32515897
PMCPMC7359109
OpenAlexW3033374941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.