Evidence map›Paper›PMID 32515888›Full record

Trial reportJournal of occupational health2020

Effects of obesity, metabolic syndrome, and non-alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J-DOIT1.

Naoki Sakane, Kazuhiko Kotani, Akiko Suganuma, Kaoru Takahashi, Juichi Sato, Sadao Suzuki, Kazuo Izumi, Masayuki Kato, Mitsuhiko Noda, Shinsuke Nirengi and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of occupational health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Naoki SakaneDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.ORCID https://orcid.org/0000-0002-2625-571X
Kazuhiko KotaniDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Akiko SuganumaDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kaoru TakahashiDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Juichi SatoDepartment of General Medicine/Family & Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sadao SuzukiDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kazuo IzumiNational Center for Global Health and Medicine, Tokyo, Japan.
Masayuki KatoHealth Management Center and Diagnostic Imaging Center, Toranomon Hospital, Tokyo, Japan.
Mitsuhiko NodaIchikawa Hospital, International University of Health and Welfare, Chiba, Japan.
Shinsuke NirengiDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.ORCID https://orcid.org/0000-0003-1881-067X
Hideshi KuzuyaDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Funding

JSPS KAKENHI 18K01988Ministry of Health, Labour and Welfare, of Japan
6 · The paper itself

Abstract

objectivesUsing annual health check-up data, the aim of this study was to identify target populations for lifestyle interventions to effectively prevent diabetes in a real-world setting.

methodsThe Japan Diabetes Outcome Intervention Trial-1, a prospective, cluster-randomized controlled trial, was launched to test if year-long telephone-delivered lifestyle support by health professionals can prevent the development of type 2 diabetes (T2D) in people with impaired fasting glucose (IFG) identified at health check-ups. A total of 2607 participants aged 20-65 years with IFG were randomized to an intervention arm (n = 1240) or a control arm (n = 1367). We performed subgroup analysis to examine the effects of the intervention on the incidence of T2D in participants with body mass index (BMI) ≥25, metabolic syndrome (MetS), and non-alcoholic or alcoholic elevated liver enzymes at the baseline. Cox regression analysis adjusted for sex was used to calculate the hazard ratios (HRs).

resultsIn addition to IFG, the presence of BMI ≥25, MetS, and elevated liver enzymes increased the incidence of diabetes by two- or three-fold. During a median follow-up period of 4.9 years, only the non-alcoholic elevated liver enzyme group showed a low incidence rate owing to lifestyle interventions (adjusted HR: 0.42, 95% confidence interval: 0.18-0.98).

conclusionThe results suggest that people who have IFG and non-alcoholic elevated liver enzymes are a good target population for lifestyle interventions to effectively reduce the incidence of diabetes in a real-world setting.

Indexed as

Life StyleAdultAgedAlanine TransaminaseAspartate AminotransferasesDiabetes Mellitus, Type 2FemaleGlucose IntoleranceHumansIncidenceJapanMaleMetabolic SyndromeMiddle AgedObesityPreventive Health ServicesAlanine TransaminaseAspartate Aminotransferasesdiabetes preventionimpaired fasting glucosenon-alcoholic fatty liver disease

Identifiers

PMID32515888
PMCPMC6971425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.