Evidence map›Paper›PMID 32515878›Full record

ArticleJournal of occupational health2020

Inter-laboratory comparison of pulmonary lesions induced by intratracheal instillation of NiO nanoparticle in rats: Histopathological examination results.

Hideki Senoh, Hirokazu Kano, Masaaki Suzuki, Shoji Fukushima, Yutaka Oshima, Toshio Kobayashi, Yasuo Morimoto, Hiroto Izumi, Yasufumi Ota, Hiroshi Takehara and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Hideki SenohJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, Japan.ORCID https://orcid.org/0000-0003-2825-4582
Hirokazu KanoJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, Japan.
Masaaki SuzukiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, Japan.
Shoji FukushimaJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, Japan.
Yutaka OshimaChemicals Evaluation and Research Institute, Hita, Japan.
Toshio KobayashiChemicals Evaluation and Research Institute, Hita, Japan.
Yasuo MorimotoUniversity of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroto IzumiUniversity of Occupational and Environmental Health, Kitakyushu, Japan.
Yasufumi OtaBioSafety Research Center Inc., Iwata, Japan.
Hiroshi TakeharaBioSafety Research Center Inc., Iwata, Japan.
Takamasa NumanoDIMS Institute of Medical Science, Inc., Ichinomiya, Japan.
Mayumi KawabeDIMS Institute of Medical Science, Inc., Ichinomiya, Japan.
Masashi GamoNational Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Jun-Ichi TakeshitaNational Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Japan Organization of Occupational Health and Safety · JPChemicals Evaluation and Research Institute · JPIwate Biotechnology Research Center · JPNational Institute of Advanced Industrial Science and Technology · JPUniversity of Occupational and Environmental Health Japan · JPJapan Association for Development of Community Medicine · JP

Funding

Development of Innovative methodology for Safety Assessment of Industrial NanomaterialsMinistry of Economy, Trade and Industry (METI)
6 · The paper itself

Abstract

objectiveIn this study, in order to investigate the usefulness of intratracheal instillation in assessing the pulmonary toxicity of nanomaterials, intratracheal instillation of nickel oxide-nanoparticles (NiO-NP) was performed.

methodsIn this study, rats were administered test materials by intratracheal instillation at five different research institutions in order to assess the validity of using intratracheal instillation for hazard identification of nanomaterials. Eight-week-old male SD rats were administered NiO-NP dispersed in deionized water by a single intratracheal instillation at doses of 0 (vehicle control), 0.2, 0.67, and 2 mg/kg BW. Three days after instillation, histopathological examination of the lungs was performed.

resultsNiO-NP was distributed in the vicinity of hilus of the lung and in the alveoli around the bronchioles. Histopathological changes such as degeneration/necrosis of macrophages, inflammation, and proliferation of type II pneumocyte in the lung were observed, and their severity corresponded with increasing dose. The histopathological observations of pulmonary toxicity were almost similar at each institution.

conclusionThe similarity of the histopathological changes observed by five independent groups indicates that intratracheal instillation can be a useful screening method to detect the pulmonary toxicity of nanomaterials.

Indexed as

AnimalsInhalation ExposureLung DiseasesMaleMetal NanoparticlesNickelRatsRats, Sprague-DawleyNickelnickel monoxideinter-laboratory comparisonintratracheal instillationnanomaterialNiOpulmonary toxicity

Identifiers

PMID32515878
PMCPMC7154589
OpenAlexW3011835024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.