ArticlePsychological medicine2022
Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.
Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.Psychological medicine · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundIt is not clear to what extent associations between schizophrenia, cannabis use and cigarette use are due to a shared genetic etiology. We, therefore, examined whether schizophrenia genetic risk associates with longitudinal patterns of cigarette and cannabis use in adolescence and mediating pathways for any association to inform potential reduction strategies.
methodsAssociations between schizophrenia polygenic scores and longitudinal latent classes of cigarette and cannabis use from ages 14 to 19 years were investigated in up to 3925 individuals in the Avon Longitudinal Study of Parents and Children. Mediation models were estimated to assess the potential mediating effects of a range of cognitive, emotional, and behavioral phenotypes.
resultsThe schizophrenia polygenic score, based on single nucleotide polymorphisms meeting a training-set
conclusionsOur study provides evidence that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence. Investigation of pathways other than the cognitive, emotional, and behavioral phenotypes examined here is required to identify modifiable targets to reduce the public health burden of cannabis use in the population.
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