ArticleRadiology2020
Identification of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer by Using HER2-targeted
Open access · greenAbstract read
In one paragraph
Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade.International journal of molecular sciences · 2022Pooled it
- Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective.EJNMMI radiopharmacy and chemistry · 2026Review
- Reply to "Critical Evaluation of HER2 PET Imaging in Metastatic Breast Cancer: Addressing Key Challenges and Future Directions" and "The Role of HER2 PET in Treatment of Breast Cancer".Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Spatial PK-PD mismatch in tumor-targeting antibodies and ADCs: from lesion access to pharmacologic execution.Frontiers in oncology · 2026Review
- Diagnosis and Treatment Response Monitoring of Liver Cancer Using Glypican-3-Targeted Single-Domain Antibody PET.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Enhancing breast cancer diagnosis: non-invasive prediction of MKI-67 (Ki67) expression using ultrasound images.BMC cancer · 2025Article
- The Evaluation of (1Molecules (Basel, Switzerland) · 2025Article
- Development and clinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025Article
- AlEuropean journal of nuclear medicine and molecular imaging · 2025Article
- Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Radiolabeled HER2-targeted molecular probes in breast cancer imaging: current knowledge and future prospective.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The need for evidence-based, outcome-focused medical imaging research for cancer management.Npj imaging · 2025Article
- New Radiopharmaceutical Tracers in Breast Cancer Diagnosis and Therapy.Anti-cancer agents in medicinal chemistry · 2025Review
- A Comprehensive Review of the Mechanisms and Clinical Development of Monoclonal Antibodies in Cancer Therapy.Advances in experimental medicine and biology · 2025Review
- Radiotracer Innovations in Breast Cancer Imaging: A Review of Recent Progress.Diagnostics (Basel, Switzerland) · 2024Review
- Molecular probes targeting HER2 PET/CT and their application in advanced breast cancer.Journal of cancer research and clinical oncology · 2024Review
- First-in-Human Evaluation of Site-Specifically LabeledJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- More on treatment de-escalation, biomarkers of response in human epidermal growth factor receptor 2 (HER2)-positive breast cancer: long-term outcomes and translational research findings of the PREDIX HER2 trial.Annals of translational medicine · 2024Article
- Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024Review
- Innovations in Positron Emission Tomography and State of the Art in the Evaluation of Breast Cancer Treatment Response.Journal of clinical medicine · 2023Review
Corrections and comments
- Commented on by
Authors and funding
12 authors at 1 institution in 1 country.
Gary A UlanerFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0002-7953-0113
Jorge A CarrasquilloFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0002-8513-5734
Christopher C RiedlFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0002-7859-6997
Randy YehFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0003-2945-5546
Vaios HatzoglouFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0003-0252-0694
Dara S RossFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).
Komal JhaveriFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).
Sarat ChandarlapatyFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).
David M HymanFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).
Brian M ZeglisFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0002-9091-744X
Serge K LyashchenkoFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).
Jason S LewisFrom the Department of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., B.M.Z., S.K.L., J.S.L.), Department of Pathology (D.S.R.), Department of Medicine (K.J., S.C., D.M.H.), and Molecular Pharmacology Program (B.M.Z., J.S.L.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065; Departments of Radiology (G.A.U., J.A.C., C.C.R., R.Y., V.H., S.K.L., J.S.L.) and Medicine (K.J., S.C., D.M.H.), Weill Cornell Medical College, New York, NY; and Department of Chemistry, Hunter College, City University of New York, New York, NY (B.M.Z.).ORCID 0000-0001-7065-4534
Memorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MLeveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2MThe Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R35 CA232130
Abstract
Background Human epidermal growth factor receptor 2 (HER2)-targeted therapies are successful in patients with HER2-positive malignancies; however, spatial and temporal heterogeneity of HER2 expression may prevent identification of optimal patients for these therapies. Purpose To determine whether imaging with the HER2-targeted PET tracer zirconium 89 (
Indexed as
Breast NeoplasmsPositron Emission Tomography Computed TomographyAgedAntibodies, Monoclonal, HumanizedAntineoplastic AgentsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedNeoplasm MetastasisProspective StudiesRadioisotopesZirconiumAntibodies, Monoclonal, HumanizedAntineoplastic AgentsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasespertuzumabRadioisotopesZirconiumZirconium-89
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.